ArticleCerebral cortex (New York, N.Y. : 1991)2016
Augmenting Plasticity Induction in Human Motor Cortex by Disinhibition Stimulation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Induction of excitatory brain state governs plastic functional changes in visual cortical topology.Brain structure & function · 2024Review
- Targeting motor cortex high-excitability states defined by functional connectivity with real-time EEG-TMS.NeuroImage · 2023Article
- Synaptic plasticity mechanisms behind TMS efficacy: insights from its application to animal models.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Age-related changes in motor cortex plasticity assessed with non-invasive brain stimulation: an update and new perspectives.Experimental brain research · 2021Review
- Motor learning enhanced by combined motor imagery and noninvasive brain stimulation is associated with reduced short-interval intracortical inhibition.Brain and behavior · 2019Article
- The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS-EEG study.Human brain mapping · 2019Article
- Posttraining Alpha Transcranial Alternating Current Stimulation Impairs Motor Consolidation in Elderly People.Neural plasticity · 2019Article
- Article
- Repetitive Transcranial Magnetic Stimulation for Upper Extremity Motor Recovery: Does It Help?Current neurology and neuroscience reports · 2018Review
- TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS-EEG and working memory performance.Human brain mapping · 2018Article
- Lifting the veil on the dynamics of neuronal activities evoked by transcranial magnetic stimulation.eLife · 2017Article
- Rehabilitating the addicted brain with transcranial magnetic stimulation.Nature reviews. Neuroscience · 2017Review
- Investigating the impact of feedback update interval on the efficacy of restorative brain-computer interfaces.Royal Society open science · 2017Article
- GABA and primary motor cortex inhibition in young and older adults: a multimodal reliability study.Journal of neurophysiology · 2017Article
- Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Review
- Transcranial brain stimulation: closing the loop between brain and stimulation.Current opinion in neurology · 2016Review
- The influence of sensory afferent input on local motor cortical excitatory circuitry in humans.The Journal of physiology · 2015Article
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5 authors.
Funding
Abstract
Cellular studies showed that disinhibition, evoked pharmacologically or by a suitably timed priming stimulus, can augment long-term plasticity (LTP) induction. We demonstrated previously that transcranial magnetic stimulation evokes a period of presumably GABA(B)ergic late cortical disinhibition (LCD) in human primary motor cortex (M1). Here, we hypothesized that, in keeping with cellular studies, LCD can augment LTP-like plasticity in humans. In Experiment 1, patterned repetitive TMS was applied to left M1, consisting of 6 trains (intertrain interval, 8 s) of 4 doublets (interpulse interval equal to individual peak I-wave facilitation, 1.3-1.5 ms) spaced by the individual peak LCD (interdoublet interval (IDI), 200-250 ms). This intervention (total of 48 pulses applied over ∼45 s) increased motor-evoked potential amplitude, a marker of corticospinal excitability, in a right hand muscle by 147% ± 4%. Control experiments showed that IDIs shorter or longer than LCD did not result in LTP-like plasticity. Experiment 2 indicated topographic specificity to the M1 hand region stimulated by TMS and duration of the LTP-like plasticity of 60 min. In conclusion, GABA(B)ergic LCD offers a powerful new approach for augmenting LTP-like plasticity induction in human cortex. We refer to this protocol as disinhibition stimulation (DIS).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.