ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- Afadin-deficient mouse retinas exhibit severe neuronal lamination defects but preserve visual functions.eLife · 2025Article
- Loss ofCells · 2024Article
- Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis.Nature neuroscience · 2023Article
- Article
- Progenitor-Based Cell Biological Aspects of Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2022Review
- Flying under the radar: CDH2 (N-cadherin), an important hub molecule in neurodevelopmental and neurodegenerative diseases.Frontiers in neuroscience · 2022Review
- Cold-induction of afadin in brown fat supports its thermogenic capacity.Scientific reports · 2021Article
- Review
- Roots of the Malformations of Cortical Development in the Cell Biology of Neural Progenitor Cells.Frontiers in neuroscience · 2021Review
- ABHD4-dependent developmental anoikis safeguards the embryonic brain.Nature communications · 2020Article
- N-cadherin (Cdh2) Maintains Migration and Postmitotic Survival of Cortical Interneuron Precursors in a Cell-Type-Specific Manner.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Persistent Cyfip1 Expression Is Required to Maintain the Adult Subventricular Zone Neurogenic Niche.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Adherens Junctions: Guardians of Cortical Development.Frontiers in cell and developmental biology · 2020Review
- The neuroanatomy of Eml1 knockout mice, a model of subcortical heterotopia.Journal of anatomy · 2019Article
- Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.EMBO reports · 2019Article
- A transient window of hypothyroidism alters neural progenitor cells and results in abnormal brain development.Scientific reports · 2019Article
- Article
- Neural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche.Frontiers in cell and developmental biology · 2019Review
- Cadherin 8 regulates proliferation of cortical interneuron progenitors.Brain structure & function · 2019Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
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Abstract
Radial glial cells (RGCs) in the ventricular neuroepithelium of the dorsal telencephalon are the progenitor cells for neocortical projection neurons and astrocytes. Here we show that the adherens junction proteins afadin and CDH2 are critical for the control of cell proliferation in the dorsal telencephalon and for the formation of its normal laminar structure. Inactivation of afadin or CDH2 in the dorsal telencephalon leads to a phenotype resembling subcortical band heterotopia, also known as "double cortex," a brain malformation in which heterotopic gray matter is interposed between zones of white matter. Adherens junctions between RGCs are disrupted in the mutants, progenitor cells are widely dispersed throughout the developing neocortex, and their proliferation is dramatically increased. Major subtypes of neocortical projection neurons are generated, but their integration into cell layers is disrupted. Our findings suggest that defects in adherens junctions components in mice massively affects progenitor cell proliferation and leads to a double cortex-like phenotype.
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