A local circadian clock calls time on lung inflammation.

A A Roger Thompson, Sarah R Walmsley, Moira K B Whyte

Abstract readComment

In one paragraph

Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.5field-weighted citation impact, top 43% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

The case for chronotherapy in Covid-19-induced acute respiratory distress syndrome.British journal of pharmacology · 2020
Review
Diurnal Variation of the Peripheral Cholinergic Antiinflammatory Function in Mice.CNS neuroscience & therapeutics · 2016
Article
Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.Scientific reports · 2015
Article

4 · The record

Corrections and comments

Comment on
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.2014

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

A A Roger ThompsonAcademic Unit of Respiratory Medicine, Department of Infection and Immunity, The Medical School, University of Sheffield, Sheffield, UK.

Sarah R WalmsleyAcademic Unit of Respiratory Medicine, Department of Infection and Immunity, The Medical School, University of Sheffield, Sheffield, UK.

Moira K B WhyteAcademic Unit of Respiratory Medicine, Department of Infection and Immunity, The Medical School, University of Sheffield, Sheffield, UK.

University of Sheffield · GB

Funding

Biotechnology and Biological Sciences Research Council BB/D004357/1Biotechnology and Biological Sciences Research Council BB/K003097/1Wellcome Trust 098516

6 · The paper itself

Abstract

Inflammatory diseases typically display circadian variation in symptom severity. A new study in mice shows how a pulmonary epithelial cell clock controls neutrophil recruitment to the lungs and provides insight into interactions between local and systemic circadian clocks.

Indexed as

Streptococcus pneumoniaeAnimalsARNTL Transcription FactorsChemokine CXCL5Circadian ClocksGlucocorticoidsHumansPneumonia, PneumococcalARNTL Transcription FactorsBmal1 protein, mouseChemokine CXCL5Cxcl5 protein, mouseGlucocorticoids

Identifiers

PMID25100521

DOI10.1038/nm.3649

OpenAlexW1974060956

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.