Trial reportEuropean radiology2014
High-pitch computed tomography pulmonary angiography with iterative reconstruction at 80 kVp and 20 mL contrast agent volume.
Trial report in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 88 citations in OpenAlex.
- Minimizing contrast media dose in CT pulmonary angiography with high-pitch technique.The British journal of radiology · 2020Trial
- Computed tomography pulmonary angiography and venography with a low dose of contrast medium.Radiological physics and technology · 2019Trial
- Deep-learning based image reconstruction enables reduced dose CT pulmonary angiography with non-inferior image quality.Scientific reports · 2026Article
- Computed tomography pulmonary angiography in around-the-clock clinical care with individualised scan protocols: a 5-year observational study on incidence and causes of repeat scanning.European radiology · 2026Observational
- Comprehensive review of pulmonary embolism imaging: past, present and future innovations in computed tomography (CT) and other diagnostic techniques.Japanese journal of radiology · 2025Review
- High-pitch CT pulmonary angiography (CTPA) with ultra-low contrast medium volume for the detection of pulmonary embolism: a comparison with standard CTPA.European radiology · 2024Article
- Improved image quality in CT pulmonary angiography using deep learning-based image reconstruction.Scientific reports · 2024Article
- Photon-counting CT for diagnosis of acute pulmonary embolism: potential for contrast medium and radiation dose reduction.European radiology · 2023Article
- Dedicated CCTA Followed by High-Pitch Scanning versus TRO-CT for Contrast Media and Radiation Dose Reduction: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Comparison of high-pitch prospective electrocardiogram-gated pulmonary CT angiography with standard CT pulmonary angiography on dual-source CT for detection of subsegmental pulmonary embolism in patients suspected of acute pulmonary embolism.Polish journal of radiology · 2022Article
- Low dose contrast media in step-and-shoot coronary angiography with third-generation dual-source computed tomography: feasibility of using 30 mL of contrast media in patients with body surface area <1.7 mQuantitative imaging in medicine and surgery · 2021Article
- Acute pulmonary embolism multimodality imaging prior to endovascular therapy.The international journal of cardiovascular imaging · 2021Review
- Establishment of CTPA Local Diagnostic Reference Levels with Noise Magnitude as a Quality Indicator in a Tertiary Care Hospital.Diagnostics (Basel, Switzerland) · 2020Article
- Pulmonary embolism during pregnancy: a 17-year single-center retrospective MDCT pulmonary angiography study.European radiology · 2020Article
- CT angiography for pulmonary embolism in the emergency department: investigation of a protocol by 20 ml of high-concentration contrast medium.La Radiologia medica · 2020Article
- Radiation dose and image quality of high-pitch emergency abdominal CT in obese patients using third-generation dual-source CT (DSCT).Scientific reports · 2019Article
- Ultra-low dose contrast CT pulmonary angiography in oncology patients using a high-pitch helical dual-source technology.Diagnostic and interventional radiology (Ankara, Turkey) · 2019Article
- Computed Tomography Pulmonary Angiography during Pregnancy: Radiation Dose of Commonly Used Protocols and the Effect of Scan Length Optimization.Korean journal of radiology · 2019Article
- Patient-specific 3D printed pulmonary artery model with simulation of peripheral pulmonary embolism for developing optimal computed tomography pulmonary angiography protocols.Quantitative imaging in medicine and surgery · 2019Article
- Optimization of computed tomography pulmonary angiography protocols using 3D printed model with simulation of pulmonary embolism.Quantitative imaging in medicine and surgery · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the image quality, radiation dose and diagnostic accuracy of 80kVp, high-pitch CT pulmonary angiography (CTPA) with iterative reconstruction using 20 ml of contrast agent.
methodsOne hundred patients with suspected pulmonary embolism (PE) were randomly divided into two groups (n = 50 each; group A, 100 kVp, 1.2 pitch, 60 ml of contrast medium and filtered back projection algorithm; group B, 80 kVp, 2.2 pitch, 20 ml of contrast medium and sinogram affirmed iterative reconstruction). Image quality, diagnostic accuracy and radiation dose were evaluated and compared.
resultsMean CT numbers of pulmonary arteries in group B were higher than those in group A (all P < 0.001). Contrast-to-noise ratio and signal-to-noise ratio of group B were higher than those of group A (both P < 0.001). There was no significant difference in subjective image quality scores between two groups (P = 0.807). The interobserver agreement was excellent (k = 0.836). There was no significant difference in diagnostic accuracy between the two groups (P > 0.05). Compared with group A, radiation dose of group B was reduced by 50.3% (P < 0.001).
conclusionsHigh-pitch CTPA at 80 kVp can obtain sufficient image quality in normal-weight individuals with 20 ml of contrast agent and half the radiation dose of a conventional CTPA protocol. KEY POINTS: CTPA is feasible at 80 kVp using only 20 ml of contrast agent. High-pitch CTPA at 80 kVp has an effective dose under 1 mSv. This CTPA protocol can obtain sufficient image quality in normal-weight individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.