ArticleJournal of the Royal Society, Interface2014
Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Impact of Force Function Formulations on the Numerical Simulation of Centre-Based Models.Bulletin of mathematical biology · 2020Article
- Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development.Developmental cell · 2020Article
- A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing.Experimental dermatology · 2019Article
- Multiscale modeling of layer formation in epidermis.PLoS computational biology · 2018Article
- A modeling study of budding yeast colony formation and its relationship to budding pattern and aging.PLoS computational biology · 2017Article
- Mechanisms of Cell Polarization.Current opinion in systems biology · 2017Article
- Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.PLoS computational biology · 2017Article
- A 3D self-organizing multicellular epidermis model of barrier formation and hydration with realistic cell morphology based on EPISIM.Scientific reports · 2017Article
- Cell Sorting and Noise-Induced Cell Plasticity Coordinate to Sharpen Boundaries between Gene Expression Domains.PLoS computational biology · 2017Article
- Gene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst.PLoS computational biology · 2017Article
- The Interplay between Wnt Mediated Expansion and Negative Regulation of Growth Promotes Robust Intestinal Crypt Structure and Homeostasis.PLoS computational biology · 2015Article
- Deciphering principles of morphogenesis from temporal and spatial patterns on the integument.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Modelling epidermis homoeostasis and psoriasis pathogenesis.Journal of the Royal Society, Interface · 2015Article
- Cell resolved, multiparticle model of plastic tissue deformations and morphogenesis.Physical biology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Skin is a complex organ tasked with, among other functions, protecting the body from the outside world. Its outermost protective layer, the epidermis, is comprised of multiple cell layers that are derived from a single-layered ectoderm during development. Using a new stochastic, multi-scale computational modelling framework, the anisotropic subcellular element method, we investigate the role of cell morphology and biophysical cell-cell interactions in the formation of this layered structure. This three-dimensional framework describes interactions between collections of hundreds to thousands of cells and (i) accounts for intracellular structure and morphology, (ii) easily incorporates complex cell-cell interactions and (iii) can be efficiently implemented on parallel architectures. We use this approach to construct a model of the developing epidermis that accounts for the internal polarity of ectodermal cells and their columnar morphology. Using this model, we show that cell detachment, which has been previously suggested to have a role in this process, leads to unpredictable, randomized stratification and that this cannot be abrogated by adjustment of cell-cell adhesion interaction strength. Polarized distribution of cell adhesion proteins, motivated by epithelial polarization, can however eliminate this detachment, and in conjunction with asymmetric cell division lead to robust and predictable development.
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