ArticleJournal of addiction medicine
The prevalence of cannabis withdrawal and its influence on adolescents' treatment response and outcomes: a 12-month prospective investigation.
Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Prevalence of Cannabis Withdrawal Symptoms Among People With Regular or Dependent Use of Cannabinoids: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- A multi-site study examining the tobacco withdrawal trajectory in people with tobacco and cannabis co-use.Drug and alcohol dependence · 2025Trial
- Engaging Youth (Adolescents and Young Adults) to Change Frequent Marijuana Use: Motivational Enhancement Therapy (MET) in Primary Care.Journal of pediatric nursingTrial
- Effectiveness of cannabis use and cannabis use disorder interventions: a European and international data synthesis.European archives of psychiatry and clinical neuroscience · 2025Review
- Intention to quit or reduce e-cigarettes, cannabis, and their co-use among a school-based sample of adolescents.Addictive behaviors · 2024Article
- Assessment of Withdrawal, Mood, and Sleep Inventories After Monitored 3-Week Abstinence in Cannabis-Using Adolescents and Young Adults.Cannabis and cannabinoid research · 2022Article
- Marijuana use in children: An update focusing on pediatric tetrahydrocannabinol and cannabidiol use.Journal of the American College of Emergency Physicians open · 2022Article
- Clinical management of cannabis withdrawal.Addiction (Abingdon, England) · 2022Review
- Progression of cannabis withdrawal symptoms in people using medical cannabis for chronic pain.Addiction (Abingdon, England) · 2021Article
- Behavioral Treatments for Adolescent Cannabis Use Disorder: a Rationale for Cognitive Retraining.Current addiction reports · 2019Article
- DSM-5 cannabis withdrawal syndrome: Demographic and clinical correlates in U.S. adults.Drug and alcohol dependence · 2019Article
- US Epidemiology of Cannabis Use and Associated Problems.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Cognitive and Mental Health Predictors of Withdrawal Severity During an Active Attempt to Cut Down Cannabis Use.Frontiers in psychiatry · 2018Article
- Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness.Preventive medicine · 2017Article
- Cannabis Withdrawal: A Review of Neurobiological Mechanisms and Sex Differences.Current addiction reports · 2017Article
- The cannabis withdrawal syndrome: current insights.Substance abuse and rehabilitation · 2017Review
- Ambivalence: Prerequisite for success in motivational interviewing with adolescents?Addiction (Abingdon, England) · 2016Review
- Memory Systems and the Addicted Brain.Frontiers in psychiatry · 2016Review
- Cannabis Withdrawal, Posttreatment Abstinence, and Days to First Cannabis Use Among Emerging Adults in Substance Use Treatment: A Prospective Study.Journal of drug issues · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWithdrawal, a diagnostic indicator of cannabis use disorder, is often minimized or ignored as a consequence of cannabis use, particularly among adolescents. This study aims to characterize cannabis withdrawal among adolescents in outpatient treatment for substance use disorder and evaluate the clinical significance of withdrawal as a predictor of substance-related outcomes.
methodsAdolescent outpatients (N = 127) reporting cannabis as their drug of choice (n = 90) were stratified by the presence of withdrawal and compared on demographic and clinical variables at treatment intake. Hierarchical linear models compared the effect of withdrawal on percentage days abstinent (PDA) and related outcomes over a 1-year follow-up period.
resultsAdolescents reporting withdrawal (40%) were more likely to meet criteria for cannabis dependence, have higher levels of substance use severity, report more substance-related consequences, and have a mood disorder. Withdrawal was not associated with PDA over the follow-up period; however, this relationship was moderated by problem recognition such that adolescents reporting withdrawal and a drug problem improved at a greater rate with respect to PDA than those who did not recognize a problem with drugs and did not report withdrawal. DISCUSSION: Withdrawal is common among adolescent outpatients and is associated with a more clinically severe profile. In this sample, all adolescents reporting withdrawal met criteria for cannabis dependence, suggesting that withdrawal is a highly specific indicator of cannabis use disorder. Although withdrawal does not seem to be independently associated with substance use outcomes posttreatment, moderating factors such as drug problem recognition should be taken into account when formulating treatment and continuing care plans.
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Registered trials
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