ArticleMicrobiologyOpen2014
Arginine promotes Proteus mirabilis motility and fitness by contributing to conservation of the proton gradient and proton motive force.
Article in MicrobiologyOpen, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Selective sugar transport supports Proteus mirabilis fitness in the urinary tract.PLoS pathogens · 2026Article
- Amino acid decarboxylation preservesmBio · 2026Article
- PstSCAB and SapBCDF are putrescine exporters inMicrobiology spectrum · 2026Article
- Arginine at the host-pathogen interface.Infection and immunity · 2025Review
- Metabolic interplay betweenmBio · 2024Article
- Differential Contribution of Hydrogen Metabolism toPathogens (Basel, Switzerland) · 2023Article
- Organ agar serves as physiologically relevant alternative forInfection and immunity · 2023Article
- Preferential catabolism of l- vs d-serine by Proteus mirabilis contributes to pathogenesis and catheter-associated urinary tract infection.Molecular microbiology · 2022Article
- The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae.Pneumonia (Nathan Qld.) · 2021Review
- Deacidification by FhlA-dependent hydrogenase is involved in urease activity and urinary stone formation in uropathogenic Proteus mirabilis.Scientific reports · 2020Article
- Cell Shape and Population Migration Are Distinct Steps ofJournal of bacteriology · 2019Article
- Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection.PLoS pathogens · 2019Article
- Explication of the Potential of 2-Hydroxy-4-Methoxybenzaldehyde in Hampering UropathogenicFrontiers in microbiology · 2019Article
- Pathogenesis ofEcoSal Plus · 2018Review
- Article
- Genes Required for the Anti-fungal Activity of a Bacterial Endophyte Isolated from a Corn Landrace Grown Continuously by Subsistence Farmers Since 1000 BC.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Swarming contributes to Proteus mirabilis pathogenicity by facilitating access to the catheterized urinary tract. We previously demonstrated that 0.1-20 mmol/L arginine promotes swarming on normally nonpermissive media and that putrescine biosynthesis is required for arginine-induced swarming. We also previously determined that arginine-induced swarming is pH dependent, indicating that the external proton concentration is critical for arginine-dependent effects on swarming. In this study, we utilized survival at pH 5 and motility as surrogates for measuring changes in the proton gradient (ΔpH) and proton motive force (μH(+) ) in response to arginine. We determined that arginine primarily contributes to ΔpH (and therefore μH(+) ) through the action of arginine decarboxylase (speA), independent of the role of this enzyme in putrescine biosynthesis. In addition to being required for motility, speA also contributed to fitness during infection. In conclusion, consumption of intracellular protons via arginine decarboxylase is one mechanism used by P. mirabilis to conserve ΔpH and μH(+) for motility.
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