ArticleBiophysical journal2014
Protrusive activity guides changes in cell-cell tension during epithelial cell scattering.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Moderately Reduced Contractility Decreases Epithelial Cell-Cell Contact Rupture Under Large External Stretch.bioRxiv : the preprint server for biology · 2026Article
- Deposited footprints let cells switch between confined, oscillatory, and exploratory migration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Vinculin is essential for sustaining normal levels of endogenous forces at cell-cell contacts.Biophysical journal · 2023Article
- E-cadherin adhesion dynamics as revealed by an accelerated force ramp are dependent upon the presence of α-catenin.Biochemical and biophysical research communications · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- α-Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions.Molecular biology of the cell · 2022Article
- Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis.Nature communications · 2022Article
- Intrinsic cell rheology drives junction maturation.Nature communications · 2022Article
- Epithelial Cell-Like Elasticity Modulates Actin-Dependent E-Cadherin Adhesion Organization.ACS biomaterials science & engineering · 2022Article
- Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cytoplasmic pressure maintains epithelial integrity and inhibits cell motility.Physical biology · 2021Article
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems.Cell communication and signaling : CCS · 2021Review
- Cell-substrate mechanics guide collective cell migration through intercellular adhesion: a dynamic finite element cellular model.Biomechanics and modeling in mechanobiology · 2020Article
- Collectively stabilizing and orienting posterior migratory forces disperses cell clusters in vivo.Nature communications · 2020Article
- Motility-limited aggregation of mammary epithelial cells into fractal-like clusters.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Traction microscopy with integrated microfluidics: responses of the multi-cellular island to gradients of HGF.Lab on a chip · 2019Article
- Spatial Proliferation of Epithelial Cells Is Regulated by E-Cadherin Force.Biophysical journal · 2018Article
- Cell-Cell Contact and Receptor Tyrosine Kinase Signaling.Cold Spring Harbor perspectives in biology · 2018Review
- Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity.The Journal of cell biology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowing how epithelial cells regulate cell-matrix and cell-cell adhesions is essential to understand key events in morphogenesis as well as pathological events such as metastasis. During epithelial cell scattering, epithelial cell islands rupture their cell-cell contacts and migrate away as single cells on the extracellular matrix (ECM) within hours of growth factor stimulation, even as adhesion molecules such as E-cadherin are present at the cell-cell contact. How the stability of cell-cell contacts is modulated to effect such morphological transitions is still unclear. Here, we report that in the absence of ECM, E-cadherin adhesions continue to sustain substantial cell-generated forces upon hepatocyte growth factor (HGF) stimulation, consistent with undiminished adhesion strength. In the presence of focal adhesions, constraints that preclude the spreading and movement of cells at free island edges also prevent HGF-mediated contact rupture. To explore the role of cell motion and cell-cell contact rupture, we examine the biophysical changes that occur during the scattering of cell pairs. We show that the direction of cell movement with respect to the cell-cell contact is correlated with changes in the average intercellular force as well as the initial direction of cell-cell contact rupture. Our results suggest an important role for protrusive activity resulting in cell displacement and force redistribution in guiding cell-cell contact rupture during scattering.
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