ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Astrocyte Store-Released Calcium Modulates Visual Cortex Synapse Development and Circuit Function.Research square · 2025Article
- Genetic tools for imaging microcirculation via plasma labeling.Anatomical science international · 2025Review
- Somatostatin-expressing interneurons induce early NO-driven and late specific astrocyte-mediated vasodilation.Nature communications · 2025Article
- Astrocyte regulation of behavioral outputs: the versatile roles of calcium.Frontiers in cellular neuroscience · 2025Review
- Astrocyte Regulation of Cerebral Blood Flow in Health and Disease.Cold Spring Harbor perspectives in biology · 2024Review
- Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19.Brain communications · 2024Review
- Astrocytic GPCR-Induced CaInternational journal of molecular sciences · 2023Article
- Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice.Nature communications · 2022Article
- Article
- Neurovascular Coupling in Development and Disease: Focus on Astrocytes.Frontiers in cell and developmental biology · 2021Review
- Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?Neurochemistry international · 2019Review
- Neural and metabolic basis of dynamic resting state fMRI.NeuroImage · 2018Review
- Physiology of Astroglia.Physiological reviews · 2018Review
- The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.Neuron · 2017Review
- Infraslow Electroencephalographic and Dynamic Resting State Network Activity.Brain connectivity · 2017Article
- Glial Calcium Waves are Triggered by Seizure Activity and Not Essential for Initiating Ictal Onset or Neurovascular Coupling.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Binaural blood flow control by astrocytes: listening to synapses and the vasculature.The Journal of physiology · 2017Review
- Article
- Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone.Neuroscience · 2016Review
- Vascular Dynamics Aid a Coupled Neurovascular Network Learn Sparse Independent Features: A Computational Model.Frontiers in neural circuits · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional magnetic resonance imaging (fMRI) is a fundamental tool to investigate human brain networks. However, the cellular mechanisms underlying fMRI signals are not fully understood. One hypothetical mechanism is the putative vascular control exerted by cytosolic calcium in perivascular astrocytes. We have performed combined fMRI-electrophysiology experiments in mice lacking the inositol 1,4,5-triphosphate-type-2 receptor, with the primary pathway of cytosolic calcium increase eliminated into astrocytes. Our results show that evoked electrophysiologic activity and fMRI signals acquired during either transient or sustained neuronal activations occur independently of these large calcium signals. This result challenges the suggested intermediary role of astrocytic calcium surges in fMRI-signal generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.