ArticleThe Journal of comparative neurology2014
Aberrant synaptic input to retinal ganglion cells varies with morphology in a mouse model of retinal degeneration.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Differences in the spatial fidelity of evoked and spontaneous signals in the degenerating retina.Frontiers in cellular neuroscience · 2022Article
- Mouse models of X-linked juvenile retinoschisis have an early onset phenotype, the severity of which varies with genotype.Human molecular genetics · 2019Article
- Editorial: Encoding Visual Features by Parallel Ganglion Cell Initiated Pathways in the Healthy, Diseased and Artificial Retina.Frontiers in cellular neuroscience · 2019Article
- Clinical Impact of Spontaneous Hyperactivity in Degenerating Retinas: Significance for Diagnosis, Symptoms, and Treatment.Frontiers in cellular neuroscience · 2018Article
- Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats.International journal of ophthalmology · 2018Article
- Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats.Journal of neurophysiology · 2017Article
- Subretinal electrical stimulation reveals intact network activity in the blind mouse retina.Journal of neurophysiology · 2016Article
- Aberrant activity in retinal degeneration impairs central visual processing and relies on Cx36-containing gap junctions.Experimental eye research · 2016Article
- Retinal remodeling in human retinitis pigmentosa.Experimental eye research · 2016Review
- Changes in ganglion cell physiology during retinal degeneration influence excitability by prosthetic electrodes.Journal of neural engineering · 2016Article
- Aberrant Activity in Degenerated Retinas Revealed by Electrical Imaging.Frontiers in cellular neuroscience · 2016Review
- Origins of spontaneous activity in the degenerating retina.Frontiers in cellular neuroscience · 2015Review
- A Novel Retinal Oscillation Mechanism in an Autosomal Dominant Photoreceptor Degeneration Mouse Model.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Retinal degeneration describes a group of disorders which lead to progressive photoreceptor cell death, resulting in blindness. As this occurs, retinal ganglion cells (RGCs) begin to develop oscillatory physiological activity. Here we studied the morphological and physiological properties of RGCs in rd1 mice, aged 30-60 days, to determine how this aberrant activity correlates with morphology. Patch-clamp recordings of excitatory and inhibitory currents were performed, then dendritic structures were visualized by infusion of fluorescent dye. Only RGCs with oscillatory activity were selected for further analysis. Oscillatory frequency and power were calculated using power spectral density analysis of recorded currents. Dendritic arbor stratification, total length, and area were measured from confocal microscope image stacks. These measurements were used to sort RGCs by cluster analysis using Ward's Method. This resulted in a total of 10 clusters, with monostratified and bistratified cells having five clusters each. Both populations exhibited correlations between arbor stratification and aberrant inhibitory input, while excitatory input did not vary with arbor distribution. These findings illustrate the relationship between aberrant activity and RGC morphology at early stages of retinal degeneration.
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