ArticleJournal of gastroenterology2015
Food antigen-induced immune responses in Crohn's disease patients and experimental colitis mice.
Article in Journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Feline chronic diarrhea: causes and nutritional management.Veterinary and animal science · 2026Review
- A Novel Approach of T Cell Receptor Classification Reveals Dynamic Interactions Amongst Diet, Microbiota, and Host T Cells.Immune network · 2025Review
- Therapeutic mechanisms of exclusive enteral nutrition in Crohn's disease.Seminars in immunopathology · 2025Review
- A hierarchy of intestinal antigens instructs the CD4Immunity · 2025Article
- Association between allergic diseases and mucosal healing in ulcerative colitis.Scientific reports · 2025Article
- Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives.Nutrients · 2024Review
- Identification of antigen-presentation related B cells as a key player in Crohn's disease using single-cell dissecting, hdWGCNA, and deep learning.Clinical and experimental medicine · 2023Article
- Immunoglobulin subtype-coated bacteria are correlated with the disease activity of inflammatory bowel disease.Scientific reports · 2021Article
- How Can a Polymeric Formula Induce Remission in Crohn's Disease Patients?International journal of molecular sciences · 2021Review
- Bidirectional regulation of bile acid on colorectal cancer through bile acid-gut microbiota interaction.American journal of translational research · 2021Review
- Capsaicin and Gut Microbiota in Health and Disease.Molecules (Basel, Switzerland) · 2020Review
- Inflammatory Bowel Disease: Are Symptoms and Diet Linked?Nutrients · 2020Article
- Repertoire analysis of memory T-cell receptors in Japanese patients with inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Activated T-effector seeds: cultivating atherosclerotic plaque through alternative activation.American journal of physiology. Heart and circulatory physiology · 2019Review
- Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.The Journal of clinical investigation · 2019Article
- Observational
- Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis.Internal medicine (Tokyo, Japan) · 2018Article
- Gastrointestinal mucosal barrier function and diseases.Journal of gastroenterology · 2016Review
- Specific immunotherapy plus Clostridium butyricum alleviates ulcerative colitis in patients with food allergy.Scientific reports · 2016Article
- Influence of an elemental diet on 5-fluorouracil-induced morphological changes in the mouse salivary gland and colon.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Crohn's disease (CD), the involvement of food antigens in immune responses remains unclear. The objective of this study was to detect immune responses against food antigens in CD patients and examine the mechanism in a mouse model of colitis.
methodsWe enrolled 98 CD patients, 50 ulcerative colitis patients, and 52 healthy controls (HCs) to compare the levels of serum immunoglobulin (Ig)Gs against 88 foods. The presence of serum IgGs against foods was also examined in interleukin (IL)-10 knockout (KO) mice in which CD4(+) T cell activation by antigenic food protein was assessed. Mice transferred with IL-10 KO cells received diets with or without food antigens, and the development of colitis was evaluated.
resultsThe prevalence of IgGs against various foods, especially vegetables, grains, and nuts, was significantly higher in CD patients than in HCs. Similarly, the prevalence of IgGs against food proteins was higher in IL-10 KO mice than in BALB/c mice. Beta-conglycinin, identified as an antigenic food proteins in IL-10 KO mice, induced CD4(+) T cell production of interferon-γ and IL-17 through dendritic cell antigen presentation. Elimination of the food antigens ameliorated the development of colitis in mice without altering the composition of their intestinal microbiota.
conclusionsIn CD colitis mice, intestinal inflammation via CD4(+) T cell hyperactivation was induced by food antigens associated with high serum IgG levels and was ameliorated by the elimination of food antigens. This disrupted immunological tolerance to food antigen, which might act as an exacerbating factor, remains to be elucidated in CD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.