ArticleTransgenic research2015
Over-expression of the MxIRT1 gene increases iron and zinc content in rice seeds.
Article in Transgenic research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 106 citations in OpenAlex.
- Zinc-solubilizing bacterial consortia: a promising approach for zinc biofortification of crops.Frontiers in microbiology · 2025Review
- Improving Rice Grain Quality Through Ecotype Breeding for Enhancing Food and Nutritional Security in Asia-Pacific Region.Rice (New York, N.Y.) · 2024Review
- Monoubiquitinated MxIRT1 acts as an iron receptor to determine MxIRT1 vacuole degradation or plasma membrane recycling via endocytosis.Plant signaling & behavior · 2022Article
- HRM and CRAC in MxIRT1 act as iron sensors to determine MxIRT1 vesicle-PM fusion and metal transport.Plant signaling & behavior · 2022Article
- Genetic Approaches for Iron and Zinc Biofortification and Arsenic Decrease in Oryza sativa L. Grains.Biological trace element research · 2022Review
- Transcriptome analysis of the response ofFrontiers in microbiology · 2022Article
- A tale of two metals: Biofortification of rice grains with iron and zinc.Frontiers in plant science · 2022Review
- Assessment of Biofortification Approaches Used to Improve Micronutrient-Dense Plants That Are a Sustainable Solution to Combat Hidden Hunger.Journal of soil science and plant nutrition · 2022Review
- Enhanced Cadmium Accumulation and Tolerance in Transgenic Hairy Roots ofLife (Basel, Switzerland) · 2020Article
- Improving nutritional quality of rice for human health.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Genetic Manipulation for Improved Nutritional Quality in Rice.Frontiers in genetics · 2020Review
- Biotechnological Approaches for Generating Zinc-Enriched Crops to Combat Malnutrition.Nutrients · 2019Review
- AhNRAMP1 Enhances Manganese and Zinc Uptake in Plants.Frontiers in plant science · 2019Article
- Targeting intracellular transport combined with efficient uptake and storage significantly increases grain iron and zinc levels in rice.Plant biotechnology journal · 2019Article
- Prospecting for Microelement Function and Biosafety Assessment of Transgenic Cereal Plants.Frontiers in plant science · 2018Review
- Genome-Wide Identification and Characterization of Long Non-Coding RNA in Wheat Roots in Response to CaFrontiers in plant science · 2018Article
- The expression of heterologous Fe (III) phytosiderophore transporter HvYS1 in rice increases Fe uptake, translocation and seed loading and excludes heavy metals by selective Fe transport.Plant biotechnology journal · 2017Article
- Contribution of Zinc Solubilizing Bacteria in Growth Promotion and Zinc Content of Wheat.Frontiers in microbiology · 2017Article
- Enhanced Grain Iron Levels in Rice Expressing anFrontiers in plant science · 2017Article
- Advances in breeding for high grain Zinc in Rice.Rice (New York, N.Y.) · 2016Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron and zinc are essential in plant and human nutrition. Iron deficiency has been one of the causes of human mortality, especially in developing countries with high rice consumption. MxIRT1 is a ferrous transporter that has been screened from an iron-efficient genotype of the apple tree, Malus xiaojinensis Cheng et Jiang. In order to produce Fe-biofortified rice with MxIRT1 to solve the Fe-deficiency problem, plant expression vectors of pCAMBIA1302-MxIRT1:GFP and pCAMBIA1302-anti MxIRT1:GFP were constructed that led to successful production of transgenic rice. The transgenic plant phenotypes showed that the expression of endogenous OsIRT1 was suppressed by anti-MxIRT1 in antisense lines that acted as an opposing control, while sense lines had a higher tolerance under Zn- and Fe-deficient conditions. The iron and zinc concentration in T3 seeds increased by three times in sense lines when compared to the wild type. To understand the MxIRT1 cadmium uptake, the MxIRT1 cadmium absorption trait was compared with AtIRT1 and OsIRT1 in transgenic rice protoplasts, and it was found that MxIRT1 had the lowest Cd uptake capacity. MxIRT1 transgenic tobacco-cultured bright yellow-2 (BY-2) cells and rice lines were subjected to different Fe conditions and the results from the non-invasive micro-test technique showed that iron was actively transported compared to cadmium as long as iron was readily available in the environment. This suggests that MxIRT1 is a good candidate gene for plant Fe and Zn biofortification.
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