ArticleJournal of neurophysiology2014
Subtype-dependent postnatal development of direction- and orientation-selective retinal ganglion cells in mice.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Experience influences the refinement of feature selectivity in the mouse primary visual thalamus.Neuron · 2025Article
- Retinal ganglion cell-derived semaphorin 6A segregates starburst amacrine cell dendritic scaffolds to organize the mouse inner retina.Development (Cambridge, England) · 2024Article
- Stimulus edges induce orientation tuning in superior colliculus.Nature communications · 2023Article
- Large-scale interrogation of retinal cell functions by 1-photon light-sheet microscopy.Cell reports methods · 2023Article
- Bi-directional Refractive Compensation for With-the-Rule and Against-the-Rule Astigmatism in Young Adults.Investigative ophthalmology & visual science · 2022Article
- Differential effects of experimental glaucoma on intrinsically photosensitive retinal ganglion cells in mice.The Journal of comparative neurology · 2022Article
- Coarse-to-fine processing drives the efficient coding of natural scenes in mouse visual cortex.Cell reports · 2022Article
- Development of Functional Properties in the Early Visual System: New Appreciations of the Roles of Lateral Geniculate Nucleus.Current topics in behavioral neurosciences · 2022Review
- Development of the vertebrate retinal direction-selective circuit.Developmental biology · 2021Review
- Arousal Modulates Retinal Output.Neuron · 2020Article
- Orientation-Selective Retinal Circuits in Vertebrates.Frontiers in neural circuits · 2018Review
- Lycium Barbarum Polysaccharides Protect Retina in rd1 Mice During Photoreceptor Degeneration.Investigative ophthalmology & visual science · 2018Article
- Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina.Scientific reports · 2017Article
- Activity-dependent development of visual receptive fields.Current opinion in neurobiology · 2017Review
- Visual Neurons in the Superior Colliculus Innervated by Islet2Frontiers in neural circuits · 2017Article
- Development of synaptic connectivity in the retinal direction selective circuit.Current opinion in neurobiology · 2016Review
- Contributions of Rod and Cone Pathways to Retinal Direction Selectivity Through Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.Scientific reports · 2016Article
- Long-Term Protection of Retinal Ganglion Cells and Visual Function by Brain-Derived Neurotrophic Factor in Mice With Ocular Hypertension.Investigative ophthalmology & visual science · 2016Article
- Role for Visual Experience in the Development of Direction-Selective Circuits.Current biology : CB · 2016Article
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Authors and funding
3 authors.
Funding
Abstract
The direction-selective ganglion cells (DSGCs) and orientation-selective ganglion cells (OSGCs) encode the directional and the orientational information of a moving object, respectively. It is unclear how DSGCs and OSGCs mature in the mouse retina during postnatal development. Here we investigated the development of DSGCs and OSGCs after eye-opening. We show that 1) DSGCs and OSGCs are present at postnatal day 12 (P12), just before eye-opening; 2) the fractions of both DSGCs and OSGCs increase from P12 to P30; 3) the development of DSGCs and OSGCs is subtype dependent; and 4) direction and orientation selectivity are two separate features of retinal ganglion cells (RGCs) in the mouse retina. We classified RGCs into different functional subtypes based on their light response properties. Compared with P12, the direction and orientation selectivity of ON-OFF RGCs but not ON RGCs became stronger at P30. The tuning width of DSGCs for both ON and ON-OFF subtypes decreased with age. For OSGCs, we divided them into non-direction-selective (non-DS) OSGCs and direction-selective OSGCs (DS&OSGCs). For DS&OSGCs, we found that there was no correlation between the direction and orientation selectivity, and that the tuning width of both ON and ON-OFF subtypes remained unchanged with age. For non-DS OSGCs, the tuning width of ON but not ON-OFF subtype decreased with development. These findings provide a foundation to reveal the molecular and synaptic mechanisms underlying the development of the direction and orientation selectivity in the retina.
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