Trial reportObesity (Silver Spring, Md.)2014
Amodal brain activation and functional connectivity in response to high-energy-density food cues in obesity.
Trial report in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Cerebellocerebral connectivity predicts body mass index: a new open-source Python-based framework for connectome-based predictive modeling.GigaScience · 2025Article
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- The Cerebellar Response to Visual Portion Size Cues Is Associated with the Portion Size Effect in Children.Nutrients · 2024Article
- Influence of insulin sensitivity on food cue evoked functional brain connectivity in children.bioRxiv : the preprint server for biology · 2024Article
- Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB).Nutrients · 2023Article
- The effects of an 8-week mindful eating intervention on anticipatory reward responses in striatum and midbrain.Frontiers in nutrition · 2023Article
- Obesity and acute stress modulate appetite and neural responses in food word reactivity task.PloS one · 2022Article
- Preference for ugly faces? -A cognitive study of attentional and memorial biases toward facial information among young females with facial dissatisfaction.Frontiers in psychology · 2022Article
- The Association between Body Mass Index and Intra-Cortical Myelin: Findings from the Human Connectome Project.Nutrients · 2021Article
- Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?Molecular psychiatry · 2021Article
- fMRI Food Cue Reactivity as a Predictor for BMI Change Following Roux-en-Y Gastric Bypass (RYGB) or Diet Intervention.Journal of obesity and chronic diseases · 2021Article
- The Nutritional Profile of Food Advertising for School-Aged Children via Television: A Longitudinal Approach.Children (Basel, Switzerland) · 2020Article
- A review of the relationship between eating behavior, obesity and functional brain network organization.Social cognitive and affective neuroscience · 2020Review
- Weight-Related Differences in Salience, Default Mode, and Executive Function Network Connectivity in Adolescents.Obesity (Silver Spring, Md.) · 2020Article
- Article
- Brain response to food cues varying in portion size is associated with individual differences in the portion size effect in children.Appetite · 2018Article
- To What Extent Memory Could Contribute to Impaired Food Valuation and Choices in Obesity?Frontiers in psychology · 2018Article
- Article
- Food portion size and energy density evoke different patterns of brain activation in children.The American journal of clinical nutrition · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveThe obesogenic environment is pervasive, yet only some people become obese. The aim was to investigate whether obese individuals show differential neural responses to visual and auditory food cues, independent of cue modality.
methodsObese (BMI 29-41, n = 10) and lean (BMI 20-24, n = 10) females underwent fMRI scanning during presentation of auditory (spoken word) and visual (photograph) cues representing high-energy-density (ED) and low-ED foods. The effect of obesity on whole-brain activation, and on functional connectivity with the midbrain/VTA, was examined.
resultsObese compared with lean women showed greater modality-independent activation of the midbrain/VTA and putamen in response to high-ED (vs. low-ED) cues, as well as relatively greater functional connectivity between the midbrain/VTA and cerebellum (P < 0.05 corrected).
conclusionsHeightened modality-independent responses to food cues within the midbrain/VTA and putamen, and altered functional connectivity between the midbrain/VTA and cerebellum, could contribute to excessive food intake in obese individuals.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.