Trial reportPloS one2014
A five-year survey of dematiaceous fungi in a tropical hospital reveals potential opportunistic species.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A Systematic Review on the Emerging Fungal Pathogen Neoscytalidium Causing Infections Worldwide.Mycopathologia · 2025Pooled it
- Dematiaceous Molds.Infectious disease clinics of North America · 2025Review
- Article
- Nigrospora oryzae causing human corneal keratitis: A case report.American journal of ophthalmology case reports · 2024Article
- Comparative genomic and phenotypic analyses of pathogenic fungi Neoscytalidium dimidiatum and Bipolaris papendorfii isolated from human skin scraping.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- A novel endophytic fungus strain ofFrontiers in microbiology · 2023Article
- Fungal Rhinosinusitis Caused by aPathogens (Basel, Switzerland) · 2022Article
- Genotyping and In Vitro Antifungal Susceptibility Profile of Neoscytalidium Species Isolates from Respiratory Tract.Mycopathologia · 2021Article
- Isolation and molecular characterization of clinical and environmental dematiaceous fungi and relatives from Iran.Current medical mycology · 2021Article
- Mycotic Keratitis-A Global Threat from the Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- First Report of Environmental Isolation of Exophiala spp. in Malaysia.Current microbiology · 2020Article
- Article
- Fungal keratitis caused byMedical mycology case reports · 2019Article
- Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing.Emerging microbes & infections · 2019Article
- In Vitro Antifungal Susceptibility of Neoscytalidium dimidiatum Clinical Isolates from Malaysia.Mycopathologia · 2017Article
- Article
- Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes.Scientific reports · 2016Article
- The genome of newly classified Ochroconis mirabilis: Insights into fungal adaptation to different living conditions.BMC genomics · 2016Article
- Identification and characterization ofPeerJ · 2016Article
- Genome Anatomy of Pyrenochaeta unguis-hominis UM 256, a Multidrug Resistant Strain Isolated from Skin Scraping.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dematiaceous fungi (black fungi) are a heterogeneous group of fungi present in diverse environments worldwide. Many species in this group are known to cause allergic reactions and potentially fatal diseases in humans and animals, especially in tropical and subtropical climates. This study represents the first survey of dematiaceous fungi in Malaysia and provides observations on their diversity as well as in vitro response to antifungal drugs. Seventy-five strains isolated from various clinical specimens were identified by morphology as well as an internal transcribed spacer (ITS)-based phylogenetic analysis. The combined molecular and conventional approach enabled the identification of three classes of the Ascomycota phylum and 16 genera, the most common being Cladosporium, Cochliobolus and Neoscytalidium. Several of the species identified have not been associated before with human infections. Among 8 antifungal agents tested, the azoles posaconazole (96%), voriconazole (90.7%), ketoconazole (86.7%) and itraconazole (85.3%) showed in vitro activity (MIC ≤ 1 µg/mL) to the largest number of strains, followed by anidulafungin (89.3%), caspofungin (74.7%) and amphotericin B (70.7%). Fluconazole appeared to be the least effective with only 10.7% of isolates showing in vitro susceptibility. Overall, almost half (45.3%) of the isolates showed reduced susceptibility (MIC >1 µg/mL) to at least one antifungal agent, and three strains (one Pyrenochaeta unguis-hominis and two Nigrospora oryzae) showed potential multidrug resistance.
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Registered trials
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