Evidence map›Paper›PMID 25098663›Full record

ArticleSynapse (New York, N.Y.)2014

Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [

William B Mathews, Hiroto Kuwabara, Kirstie Stansfield, Heather Valentine, Mohab Alexander, Anil Kumar, John Hilton, Robert F Dannals, Dean F Wong, Fabrizio Gasparini

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synapse (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. A Review of Molecular Imaging of Glutamate Receptors.Molecules (Basel, Switzerland) · 2020
    Review
  4. Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.European journal of nuclear medicine and molecular imaging · 2016
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

William B MathewsDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Hiroto KuwabaraDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Kirstie StansfieldDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Heather ValentineDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Mohab AlexanderDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Anil KumarDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
John HiltonDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Robert F DannalsDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Dean F WongDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Fabrizio GaspariniNeurosciences Discovery, Novartis Pharma AG, Basel, Switzerland.
Johns Hopkins University · USNovartis (Switzerland) · CH

Funding

IMAGING RESEARCH IN NEUROPSYCHIATRY AND DRUG ABUSEK24DA000412 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WONG, DEAN FOSTER · 2000 to 2009
$1.5M
Development of PET Radioligands for Glutamate ReceptorsR33DA016182 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MATHEWS, WILLIAM B · 2006 to 2008
$930k
NIDA NIH HHS K24 DA000412NIDA NIH HHS R33 DA016182
6 · The paper itself

Abstract

Fenobam is a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5) with inverse agonist activity and is expected to contribute to the treatment of neuropsychiatric disorders involving dysfunction of mGluR5 including Fragile X syndrome. This study examined whether [

Indexed as

[11C]ABP688fenobamglutamatemGluR5occupancyPET

Identifiers

PMID25098663
PMCPMC4320023
OpenAlexW2101015419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.