Trial reportPloS one2014
Antimicrobial resistance, virulence profiles and molecular subtypes of Salmonella enterica serovars Typhi and Paratyphi A blood isolates from Kolkata, India during 2009-2013.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of antimicrobial resistance of typhoidalThe Indian journal of medical research · 2019Pooled it
- A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.PLoS neglected tropical diseases · 2018Pooled it
- Clinically and microbiologically derived azithromycin susceptibility breakpoints for Salmonella enterica serovars Typhi and Paratyphi A.Antimicrobial agents and chemotherapy · 2015Trial
- Antimicrobial Resistance and Molecular Characterization ofInfection and drug resistance · 2024Article
- Trends in antimicrobial resistance amongst Salmonella Paratyphi A isolates in Bangladesh: 1999-2021.PLoS neglected tropical diseases · 2023Article
- Prevalence of Salmonella typhi in among febrile patients in a tertiary care hospital of South West Rajasthan.Journal of family medicine and primary care · 2022Article
- Discovery of seven novel mutations of gyrB, parC and parE in Salmonella Typhi and Paratyphi strains from Jiangsu Province of China.Scientific reports · 2020Article
- Molecular Epidemiology of Infectious Zoonotic and Livestock Diseases.Microbiology spectrum · 2020Review
- Analysis of isolates from Bangladesh highlights multiple ways to carry resistance genes in Salmonella Typhi.BMC genomics · 2019Article
- Azithromycin resistance mechanisms in typhoidal salmonellae in India: A 25 years analysis.The Indian journal of medical research · 2019Article
- Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India.The Indian journal of medical research · 2019Review
- Sensitivity Pattern OfInfection and drug resistance · 2019Article
- Genomic and Proteomic Characterizations ofFrontiers in microbiology · 2019Article
- Multi-drug resistant Salmonella enterica serovar Typhi isolates with reduced susceptibility to ciprofloxacin in Kenya.BMC microbiology · 2018Article
- High Rates of Enteric Fever Diagnosis and Lower Burden of Culture-Confirmed Disease in Peri-urban and Rural Nepal.The Journal of infectious diseases · 2018Article
- Phase I of the Surveillance for Enteric Fever in Asia Project (SEAP): An Overview and Lessons Learned.The Journal of infectious diseases · 2018Article
- Longitudinal Typhoid Fever Trends in India from 2000 to 2015.The American journal of tropical medicine and hygiene · 2018Article
- Typhoid fever: issues in laboratory detection, treatment options & concerns in management in developing countries.Future science OA · 2018Review
- Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing.Microbial genomics · 2018Review
- Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteric fever, caused by Salmonella enterica, remains an unresolved public health problem in India and antimicrobial therapy is the main mode of treatment. The objective of this study was to characterize the Salmonella enterica isolates from Kolkata with respect to their antimicrobial resistance (AMR), virulence profiles and molecular subtypes. Salmonella enterica blood isolates were collected from clinically suspected enteric fever patients attending various hospitals in Kolkata, India from January 2009 to June 2013 and were tested for AMR profiles by standard protocols; for resistance gene transfer by conjugation; for resistance and virulence genes profiles by PCR; and for molecular subtypes by Pulsed Field Gel Electrophoresis (PFGE). A total of 77 Salmonella enterica serovar Typhi (S. Typhi) and 25 Salmonella enterica serovar Paratyphi A (S. Paratyphi A) from Kolkata were included in this study. Although multidrug resistance (resistance to chloramphenicol, ampicillin, co-trimoxazole) was decreasing in S. Typhi (18.2%) and absent in S. Paratyphi A, increased resistance to fluoroquinolone, the current drug of choice, caused growing concern for typhoid treatment. A single, non-conjugative non-IncHI1 plasmid of 180 kb was found in 71.4% multidrug resistant (MDR) S. Typhi; the remaining 28.6% isolates were without plasmid. Various AMR markers (blaTEM-1, catA, sul1, sul2, dfrA15, strA-strB) and class 1 integron with dfrA7 gene were detected in MDR S. Typhi by PCR and sequencing. Most of the study isolates were likely to be virulent due to the presence of virulence markers. Major diversity was not noticed among S. Typhi and S. Paratyphi A from Kolkata by PFGE. The observed association between AMR profiles and S. Typhi pulsotypes might be useful in controlling the spread of the organism by appropriate intervention. The study reiterated the importance of continuous monitoring of AMR and molecular subtypes of Salmonella isolates from endemic regions for better understanding of the disease epidemiology.
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