ArticleArquivos brasileiros de cardiologia2014
Gender-based differences in cardiac remodeling and ILK expression after myocardial infarction.
Article in Arquivos brasileiros de cardiologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 22 citations in OpenAlex.
- Cardioprotective function of mixed spices against myocardial infarction injury: In-vivo and In-silico study.Journal, genetic engineering & biotechnology · 2025Article
- Specificities of Myocardial Infarction and Heart Failure in Women.Journal of clinical medicine · 2024Review
- Sex-Related Differences in Heart Failure Development in Patients After First Myocardial Infarction: The Role of Galectin-3.Biomedicines · 2024Article
- Strength training improves heart function, collagen and strength in rats with heart failure.The journal of physiological sciences : JPS · 2024Article
- α1A Adrenoreceptor blockade attenuates myocardial infarction by modulating the integrin-linked kinase/TGF-β/Smad signaling pathways.BMC cardiovascular disorders · 2023Article
- Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking.Biology of sex differences · 2022Article
- Suppression of SMOC2 alleviates myocardial fibrosisFrontiers in cardiovascular medicine · 2022Article
- Sex is no determinant of cardioprotection by ischemic preconditioning in rats, but ischemic/reperfused tissue mass is for remote ischemic preconditioning.Physiological reports · 2019Article
- Risks of age and sex on clinical outcomes post myocardial infarction.International journal of cardiology. Heart & vasculature · 2019Article
- Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency ofBiology of sex differences · 2017Article
- Low-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failure.Frontiers in physiology · 2017Article
- Sex differences in volume overload in skinned fibers.BMC cardiovascular disorders · 2016Article
- Sex-related differences in intrinsic myocardial properties influence cardiac function in middle-aged rats during infarction-induced left ventricular remodeling.Physiological reports · 2016Article
- Integrins and integrin-related proteins in cardiac fibrosis.Journal of molecular and cellular cardiology · 2016Review
- Coronary Artery Diseases in Women.Iranian journal of public health · 2016Article
- Association between Functional Variables and Heart Failure after Myocardial Infarction in Rats.Arquivos brasileiros de cardiologia · 2016Article
- Comparative mRNA and MicroRNA Profiling during Acute Myocardial Infarction Induced by Coronary Occlusion and Ablation Radio-Frequency Currents.Frontiers in physiology · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGender can influence post-infarction cardiac remodeling.
objectiveTo evaluate whether gender influences left ventricular (LV) remodeling and integrin-linked kinase (ILK) after myocardial infarction (MI).
methodsFemale and male Wistar rats were assigned to one of three groups: sham, moderate MI (size: 20-39% of LV area), and large MI (size: ≥40% of LV area). MI was induced by coronary occlusion, and echocardiographic analysis was performed after six weeks to evaluate MI size as well as LV morphology and function. Real-time RT-PCR and Western blot were used to quantify ILK in the myocardium.
resultsMI size was similar between genders. MI resulted in systolic dysfunction and enlargement of end-diastolic as well as end-systolic dimension of LV as a function of necrotic area size in both genders. Female rats with large MI showed a lower diastolic and systolic dilatation than the respective male rats; however, LV dysfunction was similar between genders. Gene and protein levels of ILK were increased in female rats with moderate and large infarctions, but only male rats with large infarctions showed an altered ILK mRNA level. A negative linear correlation was evident between LV dimensions and ILK expression in female rats with large MI.
conclusionsPost-MI ILK expression is altered in a gender-specific manner, and higher ILK levels found in females may be sufficient to improve LV geometry but not LV function.
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