Evidence map›Paper›PMID 25098373›Full record

Trial reportArquivos brasileiros de cardiologia2014

Effects of exercise training on heart rate variability in Chagas heart disease.

Bruno Ramos Nascimento, Márcia Maria Oliveira Lima, Maria do Carmo Pereira Nunes, Maria Clara Noman de Alencar, Henrique Silveira Costa, Marcelo Martins Pinto Filho, Vitor Emanuel Serafim Cota, Manoel Otávio da Costa Rocha, Antonio Luiz Pinho Ribeiro

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arquivos brasileiros de cardiologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01006473 (A Randomized Trial of the Effects of Exercise Training in Chagas Cardiomyopathy), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01006473 phase4completednot on this map

A Randomized Trial of the Effects of Exercise Training in Chagas Cardiomyopathy

TypeinterventionalSponsorFederal University of Minas GeraisRan2007 to 2009Enrolled37ConditionsChagas Disease, Cardiomyopathy, Exercise TrainingArmsExercise training
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. The health-related quality of life in patients with Chagas disease: the state of the art.Revista da Sociedade Brasileira de Medicina Tropical · 2022
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Cardiac Rehabilitation: Far Beyond Coronary Artery Disease.Arquivos brasileiros de cardiologia · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bruno Ramos NascimentoFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Márcia Maria Oliveira LimaFaculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
Maria do Carmo Pereira NunesFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Maria Clara Noman de AlencarServiço de Cardiologia e Cirurgia Cardiovascular, Hospital das Clínicas, UFMG, Belo Horizonte, MG, Brazil.
Henrique Silveira CostaFaculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
Marcelo Martins Pinto FilhoFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Vitor Emanuel Serafim CotaFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Manoel Otávio da Costa RochaFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Antonio Luiz Pinho RibeiroFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeart rate variability (HRV) is a marker of autonomic dysfunction severity. The effects of physical training on HRV indexes in Chagas heart disease (CHD) are not well established.

objectiveTo evaluate the changes in HRV indexes in response to physical training in CHD.

methodsPatients with CHD and left ventricular (LV) dysfunction, physically inactive, were randomized either to the intervention (IG, N = 18) or control group (CG, N = 19). The IG participated in a 12-week exercise program consisting of 3 sessions/week.

resultsMean age was 49.5 ± 8 years, 59% males, mean LVEF was 36.3 ± 7.8%. Baseline HRV indexes were similar between groups. From baseline to follow-up, total power (TP): 1653 (IQ 625 - 3418) to 2794 (1617 - 4452) ms, p = 0.02) and very low frequency power: 586 (290 - 1565) to 815 (610 - 1425) ms, p = 0.047) increased in the IG, but not in the CG. The delta (post - pre) HRV indexes were similar: SDNN 11.5 ± 30.0 vs. 3.7 ± 25.1 ms. p = 0.10; rMSSD 2 (6 - 17) vs. 1 (21 - 9) ms. p = 0.43; TP 943 (731 - 3130) vs. 1780 (921 - 2743) Hz. p = 0.46; low frequency power (LFP) 1.0 (150 - 197) vs. 60 (111 - 146) Hz. p = 0.85; except for high frequency power, which tended to increase in the IG: 42 (133 - 92) vs. 79 (61 - 328) Hz. p = 0.08).

conclusionIn the studied population, the variation of HRV indexes was similar between the active and inactive groups. Clinical improvement with physical activity seems to be independent from autonomic dysfunction markers in CHD.

Indexed as

AdultChagas DiseaseExerciseExercise TestExercise TherapyFemaleHeart RateHumansMaleMiddle AgedStatistics, NonparametricStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, Left

Identifiers

PMID25098373
PMCPMC4193067
OpenAlexW2061635705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.