ArticleAngewandte Chemie (International ed. in English)2014
Total synthesis of Δ¹²-prostaglandin J₃, a highly potent and selective antileukemic agent.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A concise and scalable chemoenzymatic synthesis of prostaglandins.Nature communications · 2024Article
- A General Catalyst Controlled Route to Prostaglandin F2Organic letters · 2022Article
- A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGFChemical science · 2021Article
- Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine.Natural product reports · 2020Review
- Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of ΔChemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
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Authors and funding
8 authors.
Funding
Abstract
A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ(12)-prostaglandin J3 (Δ(12)-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, formed enantioselectively from readily available starting materials and coupled through an aldol reaction followed by dehydration to afford stereoselectively the cyclopentenone alkylidene structural motif of the molecule.
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Registered trials
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