SynthesisTheScientificWorldJournal2014
The microRNAs as prognostic biomarkers for survival in esophageal cancer: a meta-analysis.
Synthesis in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review and Meta-analysis of the Prognostic Significance of miRNAs in Melanoma Patients.Molecular diagnosis & therapy · 2018Pooled it
- A systematic review of epigenetic biomarkers in progression from non-dysplastic Barrett's oesophagus to oesophageal adenocarcinoma.BMJ open · 2018Pooled it
- Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer.Cancer science · 2025Article
- Potential Diagnostic Utility of microRNAs in Gastrointestinal Cancers.Cancer management and research · 2023Review
- Role of miRNAs in Neurodegeneration: From Disease Cause to Tools of Biomarker Discovery and Therapeutics.Genes · 2022Review
- Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1's pro-metastatic functions in esophageal cancer.Cancer cell international · 2020Article
- Article
- MicroRNA-375 inhibits esophageal squamous cell carcinoma proliferation through direct targeting of SP1.Experimental and therapeutic medicine · 2019Article
- Overexpression of miRNA 4451 is Associated With a Poor Survival of Patients With Hypopharyngeal Cancer After Surgery With Postoperative Radiotherapy.Translational oncology · 2018Article
- Screening for esophageal squamous cell carcinoma: recent advances.Gastrointestinal endoscopy · 2018Review
- Article
- miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2.Oncology research · 2017Article
- Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14.International journal of clinical and experimental pathology · 2017Article
- From blood to breath: New horizons for esophageal cancer biomarkers.World journal of gastroenterology · 2016Review
- Article
- Non-coding RNAs deregulation in oral squamous cell carcinoma: advances and challenges.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Review
- Investigation of key miRNAs and target genes in bladder cancer using miRNA profiling and bioinformatic tools.Molecular biology reports · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe performed this meta-analysis to summarize all the results from available studies, aiming delineating the prognostic role of miRNA in esophageal cancer. DESIGN AND
methodsWe searched the electronic databases PubMed, EMBASE, and ISI Web of Science without time restrictions for the correlative literature to aggregate the survival results. Relevant data were extracted from studies investigating the relationship between miRNAs expression and survival in esophageal cancer patients. Pooled hazard ratios of miR-21 and miR-375 for OS in ESCC were calculated.
resultsA total of 25 studies involving 2,258 subjects analyzed the relationship between miRNA and prognosis of EC. In all, thirty-nine miRNAs associated with prognosis were reported in these studies. The pooled HR of higher miR-21 expression compared with lower miR-21 expression in ESCC was 1.84 (95% CI: 1.41-2.40, P < 0.001), which could significantly predict poorer OS in ESCC. Besides, higher miR-375 was also a significant predictor for OS in ESCC, with a pooled HR of 0.55 (95% CI: 0.42-0.72, P < 0.001).
conclusionsOur results support that miR-21 and miR-375 have a prognostic role in ESCC and may be useful therapeutic targets for the treatment of ESCC and meticulous follow-up for early detection of recurrence.
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