ArticleInterface focus2014
Critical transitions in a game theoretic model of tumour metabolism.
Article in Interface focus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study.PLoS computational biology · 2024Article
- Comparing mechanism-based and machine learning models for predicting the effects of glucose accessibility on tumor cell proliferation.Scientific reports · 2023Article
- Emerging role of substance and energy metabolism associated with neuroendocrine regulation in tumor cells.Frontiers in endocrinology · 2023Review
- The role of evolutionary game theory in spatial and non-spatial models of the survival of cooperation in cancer: a review.Journal of the Royal Society, Interface · 2022Review
- Lactate shuttle: from substance exchange to regulatory mechanism.Human cell · 2022Review
- Development and Validation of a 6-Gene Hypoxia-Related Prognostic Signature For Cholangiocarcinoma.Frontiers in oncology · 2022Article
- Identifying critical transitions in complex diseases.Journal of biosciences · 2022Review
- An experimental-mathematical approach to predict tumor cell growth as a function of glucose availability in breast cancer cell lines.PloS one · 2021Article
- Modeling and Analyzing Stem-Cell Therapy toward Cancer: Evolutionary Game Theory Perspective.Iranian journal of public health · 2020Article
- Metabolic reprogramming and its clinical application in thyroid cancer.Oncology letters · 2019Review
- Cooperation among cancer cells: applying game theory to cancer.Nature reviews. Cancer · 2019Review
- Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors.PLoS computational biology · 2018Article
- Rate of recovery from perturbations as a means to forecast future stability of living systems.Scientific reports · 2018Article
- Extinction rates in tumour public goods games.Journal of the Royal Society, Interface · 2017Article
- Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype.Scientific reports · 2017Article
- Nutrient deprivation-related OXPHOS/glycolysis interconversion via HIF-1α/C-MYC pathway in U251 cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.Cell cycle (Georgetown, Tex.) · 2016Article
- The mathematics of cancer: integrating quantitative models.Nature reviews. Cancer · 2015Review
- Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle.Scientific reports · 2015Article
- Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect.Cell proliferation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour proliferation is promoted by an intratumoral metabolic symbiosis in which lactate from stromal cells fuels energy generation in the oxygenated domain of the tumour. Furthermore, empirical data show that tumour cells adopt an intermediate metabolic state between lactate respiration and glycolysis. This study models the metabolic symbiosis in the tumour through the formalism of evolutionary game theory. Our game model of metabolic symbiosis in cancer considers two types of tumour cells, hypoxic and oxygenated, while glucose and lactate are considered as the two main sources of energy within the tumour. The model confirms the presence of multiple intermediate stable states and hybrid energy strategies in the tumour. It predicts that nonlinear interaction between two subpopulations leads to tumour metabolic critical transitions and that tumours can obtain different intermediate states between glycolysis and respiration which can be regulated by the genomic mutation rate. The model can apply in the epithelial-stromal metabolic decoupling therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.