ArticleEvidence-based complementary and alternative medicine : eCAM2014
An emerging translational model to screen potential medicinal plants for nephrolithiasis, an independent risk factor for chronic kidney disease.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Therapeutic effects of probiotics and herbal medications on oxalate nephrolithiasis: a mini systematic review.Iranian journal of microbiology · 2024Review
- Therapeutic effects of Chinese herbal medicines for treatment of urolithiasis: A review.Chinese herbal medicines · 2023Review
- Article
- Review
- Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021Review
- Animal Models for Studying Stone Disease.Diagnostics (Basel, Switzerland) · 2020Review
- Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome.Chinese journal of integrative medicine · 2020Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Targeted renal knockdown of NaAmerican journal of physiology. Renal physiology · 2019Article
- Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Article
- Medicinal Plants in the Prevention and Treatment of Colon Cancer.Oxidative medicine and cellular longevity · 2019Review
- Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster.BMC nephrology · 2018Article
- Toward a new insight of calcium oxalate stones in Drosophila by micro-computerized tomography.Urolithiasis · 2018Article
- Treatment of Urolithiasis with Medicinal PlantEvidence-based complementary and alternative medicine : eCAM · 2018Article
- A Review of the Antioxidant Activity of Celery ( Apium graveolens L).Journal of evidence-based complementary & alternative medicine · 2017Review
- Long-Term Therapy With Wu-Ling-San, a Popular Antilithic Chinese Herbal Formula, Did Not Prevent Subsequent Stone Surgery: A Nationwide Population-Based Cohort Study.Inquiry : a journal of medical care organization, provision and financing · 2016Article
- Corrigendum to "an emerging translational model to screen potential medicinal plants for nephrolithiasis, an independent risk factor for chronic kidney disease".Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmacological therapy for urolithiasis using medicinal plants has been increasingly adopted for the prevention of its recurrence. A Drosophila melanogaster model developed for translational research of urolithiasis was applied to evaluate agents with potential antilithic effects and calcium oxalate (CaOx) formation. Potential antilithic herbs were prepared in a mixture of food in a diluted concentration of 5,000 from the original extract with 0.5% ethylene glycol (EG) as the lithogenic agent. The control group was fed with food only. After 3 weeks, flies (n ≥ 150 for each group) were killed using CO2 narcotization, and the Malpighian tubules were dissected, removed, and processed for polarized light microscopy examination of the crystals. The crystal formation rate in the EG group was 100.0%. In the study, 16 tested herbal drugs reached the crystal formation rate of 0.0%, including Salviae miltiorrhizae, Paeonia lactiflora, and Carthami flos. Scutellaria baicalensis enhanced CaOx crystal formation. Two herbal drugs Commiphora molmol and Natrii sulfas caused the death of all flies. Our rapid screening methods provided evidence that some medicinal plants have potential antilithic effects. These useful medicinal plants can be further studied using other animal or human models to verify their effects.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.