Evidence map›Paper›PMID 25097592›Full record

ArticleArchives of medical science : AMS2014

The long head of the biceps tendon is a suitable cell source for tendon tissue regeneration.

Matthias F Pietschmann, Markus U Wagenhäuser, Mehmet F Gülecyüz, Andreas Ficklscherer, Volkmar Jansson, Peter E Müller

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Long head of biceps tendon autograft is effective in the management of large to massive rotator cuff tear: a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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  8. Impact of isolation method on cellular activation and presence of specific tendon cell subpopulations during in vitro culture.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthias F PietschmannDepartment of Orthopaedic Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Markus U WagenhäuserDepartment of Vascular and Endovascular Surgery, University of Düsseldorf, Düsseldorf, Germany.
Mehmet F GülecyüzDepartment of Orthopaedic Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Andreas FicklschererDepartment of Orthopaedic Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Volkmar JanssonDepartment of Orthopaedic Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Peter E MüllerDepartment of Orthopaedic Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTendon tissue engineering (TTE) tries to produce tendinous tissue of high quality to replace dysfunctional tissue. One possible application of TTE might be the replacement of ruptured tissue of the rotator cuff. Autologous tenocytes seem to be most suitable as no differentiation in vitro is necessary. Today it is still uncertain if there is a difference between tendon-derived cells (TDC) of different native tissues. Moreover, the search for suitable scaffolds is another important issue in TTE. MATERIAL AND

methodsThis study compared TDC of the long head of the biceps tendon (LHB), the anterior cruciate ligament (ACL) and the tendon of the musculus semitendinosus (TMS). The TDC were isolated using the cell migration method. Cell morphology was assessed using light microscopy and gene expression was performed using polymerase chain reaction (PCR). Afterwards, cell seeding efficiency and proliferation were tested on a collagen I scaffold using the WST-1 assay. Results were confirmed using H + E staining.

resultsThe TDC of the LHB showed higher expression levels of collagen type I and decorin (p < 0.01) compared to TDC of other origin. Results showed efficient cell seeding and proliferation within the scaffold. Proliferation within the scaffold was not as high as when cells were cultivated without a scaffold.

conclusionsThe TDC of the LHB seems to be the most suitable cell source. Further research is necessary to find out if the results can be transferred to an in vivo model. The new collagen I scaffold seems to offer an opportunity to combine good biocompatibility and mechanical strength.

Indexed as

rotator cuff tearsscaffoldtenocytestissue engineering

Identifiers

PMID25097592
PMCPMC4107264
OpenAlexW2076648316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.