ArticleArchives of medical science : AMS2014
Antimicrobial susceptibility of Helicobacter pylori isolates from Lower Silesia, Poland.
Article in Archives of medical science : AMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
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- A comprehensive study of Helicobacter pylori infection: molecular analysis, antibacterial susceptibility, and histopathological examination.Antonie van Leeuwenhoek · 2023Article
- Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- A High-Throughput Metabolic Microarray Assay Reveals Antibacterial Effects of Black and Red Raspberries and Blackberries againstAntibiotics (Basel, Switzerland) · 2021Article
- Rifabutin for the Treatment ofPathogens (Basel, Switzerland) · 2020Review
- Rifabutin-Containing Triple Therapy (RHB-105) for Eradication ofAntibiotics (Basel, Switzerland) · 2020Article
- The Use ofDiagnostics (Basel, Switzerland) · 2020Article
- Expression of tryptophan hydroxylase in gastric mucosa in symptomatic and asymptomaticArchives of medical science : AMS · 2019Article
- Stool antigen detection versusArchives of medical science : AMS · 2018Article
- Molecular Patterns of Resistance AmongFrontiers in microbiology · 2018Article
- Antibiotic susceptibility, heteroresistance, and updated treatment strategies inDrug design, development and therapy · 2017Review
- Colonization of multidrug resistant pathogens in a hybrid pediatric cardiac surgery center.Archives of medical science : AMS · 2016Article
- Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2015Review
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn recent years the failure of standard therapy for Helicobacter pylori infections has been observed, which results primarily from the increasing resistance of H. pylori strains to antibiotics. The aim of the study was to estimate the prevalence of antimicrobial resistance of H. pylori strains isolated from adult symptomatic patients with primary infection in the Lower Silesia Region in Poland. MATERIAL AND
methodsOne hundred and seventy-eight adults aged 19-89 years with dyspeptic symptoms suggesting gastroduodenal pathology were enrolled in the study. The study was performed in the years 2008-2011. Fifty H. pylori strains were isolated from gastric biopsy samples of examined patients. Antimicrobial susceptibility to 6 drugs (amoxicillin (AM), clarithromycin (CH), metronidazole (MZ), tetracycline (TC), levofloxacin (LEV), and rifabutin (RB)) was tested by the gradient-diffusion method (E-test method).
resultsThe incidence of H. pylori infection among examined patients was 35%. From 50 isolated H. pylori strains, 24% showed resistance to CH, 42% to MZ and 8% to LEV alone. Multidrug resistance was detected in 26% of strains, whereas 20% of isolates were resistant to MZ and CH. Examined strains were fully susceptible to AM, TC and RB.
conclusionsResistance to clarithromycin strains isolated from adults of the Lower Silesia Region in Poland is high and is almost always associated with resistance to metronidazole (CH + MZ). It is necessary to continuously monitor H. pylori resistance to drugs used in therapy, especially to clarithromycin. Verification of the existing recommendations of eradication therapy is also needed.
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