ArticleArchives of medical science : AMS2014
Nicotinic acid/laropiprant reduces platelet count but increases mean platelet volume in patients with primary dyslipidemia.
Article in Archives of medical science : AMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Mean platelet volume changes before and after glycated hemoglobin (HbAArchives of medical science : AMS · 2017Article
- Lipids, blood pressure and kidney update 2015.Lipids in health and disease · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNicotinic acid (NA) has been associated with reduced cardiovascular morbidity and mortality. Of note, beyond its lipid-modifying actions, NA possesses a number of not yet thoroughly defined pleiotropic actions including anti-inflammatory and antithrombotic effects. As a growing body of evidence points towards mean platelet volume (MPV) and platelet distribution width (PDW) as independent risk factors for cardiovascular disease, it would be interesting to evaluate the effect of NA on these platelet indices. MATERIAL AND
methodsWe recruited 50 consecutive patients with dyslipidemia who were treated with a conventional statin dose (10-40 mg simvastatin or 10-20 mg atorvastatin or 5-20 mg rosuvastatin) and had not achieved the low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (non-HDL-C) goal. Add-on-statin treatment with extended release (ER) NA/laropiprant (1,000/20 mg/day for the first 4 weeks followed by 2,000/40 mg/day for the next 8 weeks) was given to all patients for 3 months.
resultsThe ER-NA/laropiprant resulted in a 20% reduction in platelet count (from 277,150/µl (min: 163,000/µl - max: 223,400/µl) to 220,480/µl (min: 141,000/µl - max: 319,000/µl), p < 0.001), while it increased MPV by 3.5% (from 11.4 fl (min: 9.2 fl - max: 13.6 fl) to 11.8 fl (min: 9.5 fl - max: 14.1 fl), p = 0.01), without affecting PDW significantly (from 14.6 fl (min: 10.5 fl - max: 19.3 fl) to 14.5 fl (min: 11 fl - max: 21.1 fl), p = NS).
conclusionsThe NA is associated with reduced platelet count but with increased MPV, thereby raising questions regarding NA's antithrombotic and vasculoprotective properties.
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