Evidence map›Paper›PMID 25097570›Full record

ReviewArchives of medical science : AMS2014

Association of a common genetic variant in prostate stem cell antigen with cancer risk.

Li Zuo, Li Feng Zhang, Xiao Peng Wu, Zhong Xing Zhou, Jian Gang Zou, Jun He, Jian Quan Hou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Archives of medical science : AMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Review
  5. Prostate stem cell antigen variation rs2294008 associated with the risk of bladder cancer.International journal of clinical and experimental medicine · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Li ZuoDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China ; Department of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Li Feng ZhangDepartment of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Xiao Peng WuDepartment of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Zhong Xing ZhouDepartment of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Jian Gang ZouDepartment of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Jun HeJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jian Quan HouDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
First Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPolymorphisms in the prostate stem cell antigen (PSCA) gene have been hypothesized to increase the genetic susceptibility to cancers. The common sequence variation in PSCA rs2294008 (C>T) has been implicated in cancer risk. However, results of the relevant published studies were somewhat underpowered and controversial in general. MATERIAL AND

methodsTo evaluate the role of PSCA rs2294008 (C>T) genotype in global cancer, we performed a pooled analysis of all the available published studies involving 22,817 cancer patients and 27,753 control subjects.

resultsThe results showed evidence that PSCA rs2294008 (C>T) was associated with increased total cancer risk in the overall comparisons. Stratified analysis by cancer type indicated that PSCA rs2294008 T is associated with increased risk of gastric cancer (OR = 1.24, 95% CI = 1.09-1.42, p heterogeneity < 0.001, I (2) = 88.0%) and bladder cancer (OR = 1.07, 95% CI = 1.04-1.11, p heterogeneity = 0.108, I (2) = 55.0%) by allelic contrast. Furthermore, in stratified analysis by histological types of gastric cancer, this PSCA variant showed significant associations with diffuse type (OR = 1.81, 95% CI = 1.16-2.81, p heterogeneity < 0.001, I (2) = 88.9%) but not intestinal type (OR = 1.29, 95% CI = 0.95-1.74, p heterogeneity < 0.001, I (2) = 85.2%) in a dominant genetic model. Similar results were found in Asian and European descendents and population-based studies.

conclusionsIn all, our meta-analysis suggests that PSCA rs2294008 (C>T) may play allele-specific roles in cancer development. Further prospective studies with larger numbers of participants worldwide should be performed in different kinds of cancer and other descendents in more detail.

Indexed as

cancer riskmeta-analysispolymorphismprostate stem cell antigen

Identifiers

PMID25097570
PMCPMC4107248
OpenAlexW227987619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.