ArticlePakistan journal of medical sciences2014
Molecular characterization of methicillin-resistant Staphylococcus aureus isolated from tertiary care hospitals.
Article in Pakistan journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methicillin-ResistantToxins · 2020Pooled it
- Detection of livestock-associated MRSA ST398/t011 and hospital-associated MRSA ST239/t037 in a referral hospital in northeastern Iran: A six-month cross-sectional surveillance study (July-December 2025).New microbes and new infections · 2026Article
- Whole-genome sequencing to explore genomic profile, pathogenicity, virulence motifs, and pangenome of clinical MRSA isolates.Scientific reports · 2025Article
- Exploring the incidence potential of phenol-soluble modulins among methicillin-resistant Staphylococcus aureus in Lahore, Pakistan.BMC infectious diseases · 2025Article
- Panton-Valentine Leukocidin Genes and Staphylococcal Cassette Chromosome Mec Types in Methicillin-Resistant Staphylococcus aureus That Causes Hospital- and Community-Acquired Infections.The American journal of tropical medicine and hygiene · 2025Article
- Article
- Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light.Pharmaceutical biology · 2024Review
- Respiratory Carriage of Methicillin-Resistant Staphylococcus aureus-Encoding Gene in Hajj Pilgrims.Journal of epidemiology and global health · 2024Article
- Transmission of Antimicrobial Resistant Bacteria at the Hajj: A Scoping Review.International journal of environmental research and public health · 2022Article
- Role of Bioaerosols on the Short-Distance Transmission of Multidrug-Resistant Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Genomic Investigation of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Molecular Evaluation of Traditional Chicken Farm-Associated Bioaerosols for Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Genotypic Characterization of Clinical Isolates ofPathogens (Basel, Switzerland) · 2021Article
- The Emergence, Persistence, and Dissemination of Antimicrobial-Resistant Bacteria in Environmental Hajj Settings and Implications for Public Health.Tropical medicine and infectious disease · 2021Review
- Prevalence and Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Epidemiology of Methicillin-Resistant Staphylococcus Aureus in Arab Countries of the Middle East and North African (MENA) Region.Mediterranean journal of hematology and infectious diseases · 2021Article
- Antibiotic resistance and genotyping ofJournal of advanced veterinary and animal research · 2020Article
- Increased resistance of a methicillin-resistant Staphylococcus aureus Δagr mutant with modified control in fatty acid metabolism.AMB Express · 2020Article
- Novel determination ofNew microbes and new infections · 2020Article
- A descriptive analysis of PVL-positive multidrug-resistant Staphylococcus aureus in hospital-associated infections in Saudi Arabia.Bioinformation · 2020Article
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Abstract
BACKGROUND AND
objectivesMethicillin-resistant S. aureus (MRSA) tends to be resistant to multiple antibiotics. Methicillin resistance is conferred by the acquisition of the mecA gene, which is carried by a mobile genetic element called the staphylococcal cassette chromosome mec (SCCmec). There are five major types of SCCmec elements (I-V). The majority of hospital-acquired MRSA (HA-MRSA) strains carry SCCmec types I, II, or III, whereas community-acquired MRSA (CA-MRSA) strains carry SCCmec types IV or V. In addition, Panton-Valentine Leucocidin (PVL) is a gene encoding a powerful cytotoxin that is strongly associated with CA-MRSA strains. The present study was aimed to identify the types of SCCmec and PVL genes among clinical MRSA isolates.
methodsThis study was conducted in 5 tertiary care hospitals in Makkah city from March to September of 2012. A total of 206 S. aureus clinical isolates were analysed using standard microbiological methods. Multiplex PCR was performed on genomic DNA from MRSA isolates in order to identify the types of SCCmec. In addition, PCR was performed to detect the PVL gene among the isolates.
resultsOf the 206 S. aureus isolates, 114 (55.3%) were MRSA, and 100 of the MRSA isolates carried the mecA gene. RESULTS from SCCmec typing revealed that 3% were type I; 9% were type II; 47% were type III, and 29% were type IV. Nineteen per cent of the isolates harboured the PVL gene. Furthermore, there was a statistically significant correlation between the presence of the PVL gene and SCCmec type IV.
conclusionThe virulence of MRSA strains is increasing in both hospital and community settings in Makkah, highlighting the importance of their rapid identification in order to appropriately control infection.
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