Evidence map›Paper›PMID 25097461›Full record

ArticleDigital journal of ophthalmology : DJO2014

A survey of preoperative blood tests in primary open-angle glaucoma patients versus cataract surgery patients.

Laura P Cohen, Jessica Wong, Aliya Z Jiwani, Scott H Greenstein, Stacey C Brauner, Sherleen C Chen, Angela V Turalba, Teresa C Chen, Lucy Shen, Douglas J Rhee and 4 more

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Article in Digital journal of ophthalmology : DJO, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Laura P CohenGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Jessica WongGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Aliya Z JiwaniGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Scott H GreensteinComprehensive Ophthalmology Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Stacey C BraunerGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts; ; Comprehensive Ophthalmology Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Sherleen C ChenComprehensive Ophthalmology Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Angela V TuralbaGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Teresa C ChenGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Lucy ShenGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Douglas J RheeGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Janey L WiggsGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Jae Hee KangChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Stephanie LoomisGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts;
Louis R PasqualeGlaucoma Service, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts; ; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate biomarker differences in routine preoperative blood tests performed on primary open-angle glaucoma (POAG) case and control patients presenting for anterior segment eye surgery.

methodsPOAG cases and age-related cataract surgery patients (controls) who underwent anterior segment surgery at Massachusetts Eye and Ear from January 2009 through March 2012 were identified by retrospective record review. Patients with diabetes mellitus, secondary glaucoma, and cataract due to trauma or steroid exposure were excluded. Data on demographic features, preoperative ophthalmological and medical diagnosis, blood pressure, anthropometric measures, basic metabolic panel, and complete blood count were extracted from the medical records. Univariate differences in lab values between POAG cases and controls were assessed using unpaired t tests. Multivariate logistic regression analysis was completed to determine the independent associations of biomarkers with POAG.

resultsA total of 150 cases and 150 age-related controls were included. In multivariate analysis, higher AG was inversely associated with POAG (odds ratio [OR] = 0.90; 95% confidence interval [CI], 0.80-1.00), and higher Cl- level was positively associated with POAG (OR = 1.15; 95% CI, 1.02-1.29). The lower AG in POAG patients could be explained by higher IgG levels as the available data in post hoc analysis showed a nonsignificant trend toward higher IgG in cases compared to controls (17 vs 23; 1142 ± 284 mg/dl vs 1028 ± 291 mg/dl; P = 0.22). Furthermore, in multivariable analysis, a higher red blood cell count was also associated with POAG (OR = 1.91; 95% CI, 1.11-3.28).

conclusionsPatients with POAG presenting for anterior segment surgery had a lower AG compared to age-related cataract surgery patients. The etiology of this reduced gap is unclear but the possible contribution of IgG warrants further exploration. The etiology of higher red blood cell counts in POAG cases is unknown and deserves further exploration.

Indexed as

Acid-Base EquilibriumAdultAgedAged, 80 and overBiomarkersCase-Control StudiesCataractCataract ExtractionFemaleGlaucoma, Open-AngleHumansImmunoglobulin GMaleMiddle AgedPotassiumPreoperative PeriodBiomarkersImmunoglobulin GPotassium

Identifiers

PMID25097461
PMCPMC4120802

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.