ArticleIndian journal of pharmacology
Anti-psoriatic activity of Givotia rottleriformis in rats.
Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 15 citations in OpenAlex.
- The Influence of Phytoconstituents for the Management of Antipsoriatic Activity in Various Animal Models.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the antipsoriatic activity of Givotia rottleriformis bark in rats. MATERIALS AND
methodsThe antipsoriatic activity of the ethanol extract was investigated using ultraviolet B (UV-B)-induced photodermatitis model in rats. The animals were divided into four groups (6/groups). The vehicle-control group animals received normal saline (10 ml/kg, p.o.) and standard group received retinoic acid (0.5 mg/kg, p.o.). Remaining groups were treated orally with the ethanolic extract of bark of Givotia rottleriformis (200 and 400 mg/kg, p.o.) and data were analyzed using one-way analysis of variance (ANOVA). The extract was standardized using chemical markers by high-performance liquid chromatography (HPLC) analysis.
resultsIn case of psoriasis model, histopathological analysis revealed that in the section, there were absence of Munro's microabscess, elongation of rete ridges, and capillary loop dilation in ethanol extract (400 mg/Kg) and standard group. The ethanolic extract (200 and 400 mg/Kg) exhibited significant reduction (P < 0.01) in percentage of relative epidermal thickness as compared with positive control. In the HPLC analysis, 4 flavonoids were quantified by comparison to a calibration curve derived from the standard, rutin (0.215 mg/gm) quercetin (1.36 mg/gm), kaempferol (6.36 mg/gm) and luteolin (8.64 mg/gm).
conclusionThe crude extract containing ethanolic extract of Givotia rottleriformis bark have potent antipsoriatic activity in UV-B-induced psoriasis in rat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.