Evidence map›Paper›PMID 25097227›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2014

Metabolism and disposition of bupropion in pregnant baboons (Papio cynocephalus).

Erik Rytting, Xiaoming Wang, Daria I Vernikovskaya, Ying Zhan, Cassondra Bauer, Susan M Abdel-Rahman, Mahmoud S Ahmed, Tatiana N Nanovskaya

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Placental control of drug delivery.Advanced drug delivery reviews · 2017
    Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Erik RyttingDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.).
Xiaoming WangDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.).
Daria I VernikovskayaDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.).
Ying ZhanDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.).
Cassondra BauerDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.).
Susan M Abdel-RahmanDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.).
Mahmoud S AhmedDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.).
Tatiana N NanovskayaDepartment of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas (E.R., X.W., D.I.V., Y.Z., M.S.A., T.N.N.); Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas (C.B.); and Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, Missouri (S.M.A.-R.) tnnanovs@utmb.edu.
The University of Texas Medical Branch at Galveston · USChildren's Mercy Hospital · USTexas Biomedical Research Institute · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GOLDBERG, ERWIN · 1999 to 2011
$79.1M
Development of Bupropion for Smoking Cessation During PregnancyR01DA024094 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI NANOVSKAYA, TATIANA · 2007 to 2011
$1.5M
NCRR NIH HHS P51 RR013986NCRR NIH HHS P51-RR013986NIDA NIH HHS R01 DA024094NIDA NIH HHS R01-DA024094NIH HHS P51 OD011133
6 · The paper itself

Abstract

Recent in vitro data obtained in our laboratory revealed similarities between baboons and humans in the biotransformation of bupropion (BUP) by both hepatic and placental microsomes. These data supported the use of baboons to study BUP biotransformation during pregnancy. The aim of this investigation was to determine the pharmacokinetics of BUP in baboons during pregnancy and postpartum, as well as fetal exposure to the drug after intravenous administration. Pregnant baboons (n = 5) received a single intravenous bolus dose of bupropion hydrochloride (1 mg/kg) at gestational ages 94-108 days (midpregnancy), 142-156 days (late pregnancy), and 6 weeks postpartum. Blood and urine samples were collected for 12 and 24 hours, respectively. The concentrations of BUP, hydroxybupropion (OH-BUP), threohydrobupropion, and erythrohydrobupropion in plasma were determined by liquid chromatography-tandem mass spectrometry. Relative to the postpartum period, the average midpregnancy clearance of BUP trended higher (3.6 ± 0.15 versus 2.7 ± 0.28 l/h per kg) and the average C(max) (294 ± 91 versus 361 ± 64 ng/ml) and the area under the curve (AUC) of BUP values (288 ± 22 versus 382 ± 42 h·ng/ml) trended lower. AUC(OH-BUP) also tended to be lower midpregnancy compared with postpartum (194 ± 76 versus 353 ± 165 h·ng/ml). Whereas the observed trend toward increased clearance of BUP during baboon pregnancy could be associated with a pregnancy-induced increase in its biotransformation, the trend toward increased renal elimination of OH-BUP may overshadow any corresponding change in the hydroxylation activity of CYP2B.

Indexed as

AnimalsBiotransformationBupropionFemalePapio cynocephalusPostpartum PeriodPregnancyPregnancy, AnimalBupropion

Identifiers

PMID25097227
PMCPMC4164976
OpenAlexW2162711027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.