ReviewCurrent hypertension reports2014
Chemoreflexes, sleep apnea, and sympathetic dysregulation.
Review in Current hypertension reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Influence and implications of the renin-angiotensin-aldosterone system in obstructive sleep apnea: An updated systematic review and meta-analysis.Journal of sleep research · 2023Pooled it
- Clinical safety and hemodynamic, cardiac autonomic and inflammatory responses to a single session of inspiratory muscle training in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2022Trial
- Acute inorganic nitrate supplementation and the hypoxic ventilatory response in patients with obstructive sleep apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Melatonin and oxidative DNA damage in REM- and NREM-related obstructive sleep apnea: an exploratory analysis of sleep-stage phenotypes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Non-contact on-device detection of obstructive sleep apnea from infrared video.Nature communications · 2026Article
- Integrated Pulmonary Severity Score (IPSS) for COPD: A Psycho-Respiratory Risk Index Supported by Explainable Machine Learning.Diagnostics (Basel, Switzerland) · 2026Article
- Electrocardiographic Alterations in Obstructive Sleep Apnea Syndrome: Mechanisms and Clinical Relevance.Life (Basel, Switzerland) · 2026Review
- Autonomic-vascular dysregulation in CKD-associated hypertension: a narrative review with evidence hierarchy.Frontiers in neuroscience · 2026Review
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025Review
- Obstructive sleep apnea risk and predictors among children in Boston and Lebanon.Journal of orthodontic science · 2025Article
- Nocturia and obstructive sleep apnoea.Nature reviews. Urology · 2024Review
- The Dynamics of Heart Rate Asymmetry and Situational Sleepiness from Evening to Night: The Role of Daytime Sleepiness.Biology · 2024Article
- Article
- Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes.Current cardiology reports · 2024Review
- Revisiting the Role of Serotonin in Sleep-Disordered Breathing.International journal of molecular sciences · 2024Review
- Link Between Obstructive Sleep Apnea and Kidney Stones: NHANES 2015-2018 and Mendelian Randomization.Nature and science of sleep · 2024Article
- Obstructive sleep apnea mouth breathing phenotype response to combination oral appliance therapy.Frontiers in sleep · 2024Article
- Genetic overlap between major depressive disorder and obstructive sleep apnea.Frontiers in psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Obstructive sleep apnea (OSA) and hypertension are closely linked conditions. Disordered breathing events in OSA are characterized by increasing efforts against an occluded airway while asleep, resulting in a marked sympathetic response. This is predominantly due to hypoxemia activating the chemoreflexes, resulting in reflex increases in sympathetic neural outflow. In addition, apnea - and the consequent lack of inhibition of the sympathetic system that occurs with lung inflation during normal breathing - potentiates central sympathetic outflow. Sympathetic activation persists into the daytime, and is thought to contribute to hypertension and other adverse cardiovascular outcomes. This review discusses chemoreflex physiology and sympathetic modulation during normal sleep, as well as the sympathetic dysregulation seen in OSA, its extension into wakefulness, and changes after treatment. Evidence supporting the role of the peripheral chemoreflex in the sympathetic dysregulation seen in OSA, including in the context of comorbid obesity, metabolic syndrome, and systemic hypertension, is reviewed. Finally, alterations in cardiovascular variability and other potential mechanisms that may play a role in the autonomic imbalance in OSA are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.