Evidence map›Paper›PMID 25097085›Full record

ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2015

CMV in the gut: a critical review of CMV detection in the immunocompetent host with colitis.

A L Goodman, C D Murray, J Watkins, P D Griffiths, D P Webster

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03467841 (Cytomegalovirus Infection in Steroid-refractory Ulcerative Colitis), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03467841 unknown statusnot on this mapstarted 2018, after this paper: background citation

Cytomegalovirus Infection in Steroid-refractory Ulcerative Colitis

TypeobservationalSponsorDr mohammedRmadan hamadRan2018 to 2019Enrolled50ConditionsCmv ColitisArmsCMV IgM, IgG in blood real time PCR for serum CMV DNA .
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
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  6. Review
  7. Review
  8. Article
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  13. Review
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  15. Article
  16. Segmental cytomegalovirus colitis mimicking sigmoid tumor in an immunocompetent patient.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019
    Article
  17. Diagnosis and Management of CMV Colitis.Current infectious disease reports · 2019
    Review
  18. Checkpoint inhibitors: What gastroenterologists need to know.World journal of gastroenterology · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

A L GoodmanDepartment of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK. anna.goodman@nhs.net.
C D MurrayDepartment of Gastroenterology, Royal Free London NHS Foundation Trust, London, NW3 2QG, UK.
J WatkinsDepartment of Cellular Pathology, Royal Free London NHS Foundation Trust, London, NW3 2QG, UK.
P D GriffithsCentre for Virology, University College London Medical School, Rowland Hill Street, London, NW3 2PF, UK.
D P WebsterCentre for Virology, University College London Medical School, Rowland Hill Street, London, NW3 2PF, UK.
Royal Free London NHS Foundation Trust · GBUniversity College London · GBUCL Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As scientific techniques for the detection of cytomegalovirus (CMV) improve, we are able to detect small amounts of CMV in the mucosal wall. As clinicians, we are unsure how to interpret the results of this novel test. There is controversy in the literature as to the significance of the detection of CMV in the gut. Whilst the importance of CMV and reactivation of the virus is clear in those patients such as allograft recipients with established immune compromise, the role is less clear in patients with less damaged immune systems. We explore whether the detection of CMV in such cases influences outcome and how it should be optimally managed. We discuss the optimal management of such cases, according to current guidelines, with a review of the literature.

Indexed as

ColitisCytomegalovirusCytomegalovirus InfectionsHumansIntestinal Mucosa

Identifiers

PMID25097085
PMCPMC4281362
OpenAlexW2015914003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.