ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2014
Obstructive sleep apnea and the prevalence and incidence of cancer.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Obstructive sleep apnea and the risk of mortality in patients with lung cancer: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Association of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Pooled it
- Sleep Disorders in Cancer-A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Nocturnal Melatonin Deficiency in Colorectal Cancer: Independent Predictive Value Beyond Sleep Quality.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Association of nasopharynx cancer with obstructive sleep apnea.Frontiers in oncology · 2026Article
- Obstructive sleep apnea as a modifier of endocrine toxicities associated with immune checkpoint inhibitors in lung cancer.Frontiers in immunology · 2026Review
- Cancer and obstructive sleep apnea.Chinese medical journal · 2025Article
- Effects of a physical activity intervention on sleep among cancer survivors in a randomized controlled trial within the Cancer Prevention Study-3 cohort.Journal of cancer survivorship : research and practice · 2025Article
- Sleep disorders in cancer: interactions and intrinsic links.Frontiers in oncology · 2025Review
- Role of β-adrenergic signaling and the NLRP3 inflammasome in chronic intermittent hypoxia-induced murine lung cancer progression.Respiratory research · 2024Article
- Obstructive sleep apnea severity, circulating biomarkers, and cancer risk.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Exosomal miR-106a-5p derived from intermittently hypoxic non-small-cell lung cancer increases tumor malignancy.Physiological reports · 2024Article
- Revealing the Causal Impact of Obstructive Sleep Apnea on Cancer Risk: Insights from Mendelian randomization analysis.Sleep & breathing = Schlaf & Atmung · 2024Article
- Obstructive sleep apnea and 19 gastrointestinal diseases: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort.BMJ open · 2023Article
- Screening for obstructive sleep apnea in patients with cancer - a machine learning approach.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Review
- Sleep Disorders and Quality of Life in Patients With Cancer: Prospective Observational Study of the Rafael Institute.JMIR formative research · 2022Article
- Polysomnographic Markers of Obstructive Sleep Apnea Severity and Cancer-related Mortality: A Large Retrospective Multicenter Clinical Cohort Study.Annals of the American Thoracic Society · 2022Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA link between obstructive sleep apnea and cancer development or progression has been suggested, possibly through chronic hypoxemia, but supporting evidence is limited. We examined the association between the severity of obstructive sleep apnea and prevalent and incident cancer, controlling for known risk factors for cancer development.
methodsWe included all adults referred with possible obstructive sleep apnea who underwent a first diagnostic sleep study at a single large academic hospital between 1994 and 2010. We linked patient data with data from Ontario health administrative databases from 1991 to 2013. Cancer diagnosis was derived from the Ontario Cancer Registry. We assessed the cross-sectional association between obstructive sleep apnea and prevalent cancer at the time of the sleep study (baseline) using logistic regression analysis. Cox regression models were used to investigate the association between obstructive sleep apnea and incident cancer among patients free of cancer at baseline.
resultsOf 10 149 patients who underwent a sleep study, 520 (5.1%) had a cancer diagnosis at baseline. Over a median follow-up of 7.8 years, 627 (6.5%) of the 9629 patients who were free of cancer at baseline had incident cancer. In multivariable regression models, the severity of sleep apnea was not significantly associated with either prevalent or incident cancer after adjustment for age, sex, body mass index and smoking status at baseline (apnea-hypopnea index > 30 v. < 5: adjusted odds ratio [OR] 0.96, 95% confidence interval [CI] 0.71-1.30, for prevalent cancer, and adjusted hazard ratio [HR] 1.02, 95% CI 0.80-1.31, for incident cancer; sleep time spent with oxygen saturation < 90%, per 10-minute increase: adjusted OR 1.01, 95% CI 1.00-1.03, for prevalent cancer, and adjusted HR 1.00, 95% CI 0.99-1.02, for incident cancer).
interpretationIn a large cohort, the severity of obstructive sleep apnea was not independently associated with either prevalent or incident cancer. Additional studies are needed to elucidate whether there is an independent association with specific types of cancer.
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