Evidence map›Paper›PMID 25096289›Full record

ArticleIntegrative and comparative biology2014

Pulmonary fluid flow challenges for experimental and mathematical modeling.

Rachel Levy, David B Hill, M Gregory Forest, James B Grotberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative and comparative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Complex Wave Packet Dynamics Induced by Marangoni Stresses.Industrial & engineering chemistry research · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Challenge in particle delivery to cells in a microfluidic device.Drug delivery and translational research · 2018
    Article
  11. Drop spreading with random viscosity.Proceedings. Mathematical, physical, and engineering sciences · 2016
    Article
  12. Article
  13. Coming to terms with tissue engineering and regenerative medicine in the lung.American journal of physiology. Lung cellular and molecular physiology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel Levy*Department of Mathematics, Harvey Mudd College, Claremont, CA 91711, USA; The Marsico Lung Institute, Department of Physics and Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Mathematics, Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; NASA Bioscience and Engineering Institute, The University of Michigan, Ann Arbor, MI 48109, USA levy@hmc.edu.
David B Hill*Department of Mathematics, Harvey Mudd College, Claremont, CA 91711, USA; The Marsico Lung Institute, Department of Physics and Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Mathematics, Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; NASA Bioscience and Engineering Institute, The University of Michigan, Ann Arbor, MI 48109, USA.
M Gregory Forest*Department of Mathematics, Harvey Mudd College, Claremont, CA 91711, USA; The Marsico Lung Institute, Department of Physics and Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Mathematics, Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; NASA Bioscience and Engineering Institute, The University of Michigan, Ann Arbor, MI 48109, USA.
James B Grotberg*Department of Mathematics, Harvey Mudd College, Claremont, CA 91711, USA; The Marsico Lung Institute, Department of Physics and Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Mathematics, Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; NASA Bioscience and Engineering Institute, The University of Michigan, Ann Arbor, MI 48109, USA.

Funding

The Biophysics of Mucus Hydration and Adhesion/CohesionP01HL108808 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2012 to 2021
$23.9M
Virtual Lung Project: Integrated Modeling of EpithelialR01HL077546 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUPERFINE, RICHARD · 2006 to 2010
$3.6M
Microfluidic Tissue Engineering of Small Airway InjuriesR01HL084370 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAKAYAMA, SHUICHI · 2006 to 2010
$2.8M
Stability of Pullmonary AirwaysR01HL085156 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GROTBERG, JAMES BERNARD · 2007 to 2010
$1.5M
PULMONARY MASS AND HEAT TRANSPORTR01HL041126 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GROTBERG, JAMES B · 1988 to 2002
$609k
NHLBI NIH HHS 1 P01HL108808-01A1NHLBI NIH HHS 5 R01 HL077546-05NHLBI NIH HHS HL 41126NHLBI NIH HHS HL 84370NHLBI NIH HHS HL 85156
6 · The paper itself

Abstract

Modeling the flow of fluid in the lungs, even under baseline healthy conditions, presents many challenges. The complex rheology of the fluids, interaction between fluids and structures, and complicated multi-scale geometry all add to the complexity of the problem. We provide a brief overview of approaches used to model three aspects of pulmonary fluid and flow: the surfactant layer in the deep branches of the lung, the mucus layer in the upper airway branches, and closure/reopening of the airway. We discuss models of each aspect, the potential to capture biological and therapeutic information, and open questions worthy of further investigation. We hope to promote multi-disciplinary collaboration by providing insights into mathematical descriptions of fluid-mechanics in the lung and the kinds of predictions these models can make.

Indexed as

HydrodynamicsModels, BiologicalExtravascular Lung WaterHumansLungRheology

Identifiers

PMID25096289
PMCPMC4296202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.