Evidence map›Paper›PMID 25095886›Full record

Trial reportCirculation2014

Improved quality of life after 1 year with an invasive versus a noninvasive treatment strategy in claudicants: one-year results of the Invasive Revascularization or Not in Intermittent Claudication (IRONIC) Trial.

Joakim Nordanstig, Charles Taft, Marlene Hensäter, Angelica Perlander, Klas Osterberg, Lennart Jivegård

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Guideline
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  3. Pooled it
  4. Pooled it
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  6. Guideline
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  8. Trial
  9. Review
  10. Article
  11. Review
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  14. Observational
  15. Article
  16. Comparison of three generic quality-of-life metrics in peripheral arterial disease patients undergoing conservative and invasive treatments.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
    Article
  17. Review
  18. Article
  19. Claudication: Pay for Structured Exercise or Go Take a Hike.JACC. Cardiovascular interventions · 2017
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joakim NordanstigFrom the Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital and Academy (J.N., M.H., A.P., K.O., L.J.); and Health and Care Sciences and Gothenburg University Center for Person-Centered Care, Gothenburg University (C.T.), Gothenburg, Sweden. joakim.nordanstig@vgregion.se.
Charles TaftFrom the Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital and Academy (J.N., M.H., A.P., K.O., L.J.); and Health and Care Sciences and Gothenburg University Center for Person-Centered Care, Gothenburg University (C.T.), Gothenburg, Sweden.
Marlene HensäterFrom the Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital and Academy (J.N., M.H., A.P., K.O., L.J.); and Health and Care Sciences and Gothenburg University Center for Person-Centered Care, Gothenburg University (C.T.), Gothenburg, Sweden.
Angelica PerlanderFrom the Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital and Academy (J.N., M.H., A.P., K.O., L.J.); and Health and Care Sciences and Gothenburg University Center for Person-Centered Care, Gothenburg University (C.T.), Gothenburg, Sweden.
Klas OsterbergFrom the Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital and Academy (J.N., M.H., A.P., K.O., L.J.); and Health and Care Sciences and Gothenburg University Center for Person-Centered Care, Gothenburg University (C.T.), Gothenburg, Sweden.
Lennart JivegårdFrom the Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital and Academy (J.N., M.H., A.P., K.O., L.J.); and Health and Care Sciences and Gothenburg University Center for Person-Centered Care, Gothenburg University (C.T.), Gothenburg, Sweden.
University of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe quality of evidence for invasive revascularization in intermittent claudication is low or very low. This prospective, randomized, controlled study tested the hypothesis that an invasive treatment strategy versus continued noninvasive treatment improves health-related quality of life after 1 year in unselected patients with intermittent claudication. METHODS AND

resultsAfter clinical and duplex ultrasound assessment, unselected patients with intermittent claudication requesting treatment for claudication were randomly assigned to invasive (n=79) or noninvasive (n=79) treatment groups. Primary end point was health-related quality of life after 1 year, assessed with Medical Outcomes Study Short Form 36 version 1 and Vascular Quality of Life Questionnaire, and secondary end points included walking distances on a graded treadmill. The Medical Outcomes Study Short Form 36 version 1 physical component summary (P<0.001) and 2 Medical Outcomes Study Short Form 36 version 1 physical subscales improved significantly more in the invasive versus the noninvasive treatment group. Overall, Vascular Quality of Life Questionnaire score (P<0.01) and 3 of 5 domain scores improved significantly more in the invasive versus the noninvasive treatment group. Intermittent claudication distance improved significantly in the invasive (+124 m) versus the noninvasive (+50 m) group (P=0.003), whereas the change in maximum walking distance was not significantly different between groups.

conclusionsAn invasive treatment strategy improves health-related quality of life and intermittent claudication distance after 1 year in patients with stable lifestyle-limiting claudication receiving current medical management. Long-term follow-up data and health-economic assessments are warranted to further establish the role for revascularization in intermittent claudication.

Indexed as

Quality of LifeAgedFemaleHumansIntermittent ClaudicationMaleMiddle AgedProspective StudiesSurveys and Questionnairesintermittent claudicationperipheral arterial diseasequality of liferevascularization

Identifiers

PMID25095886
OpenAlexW2103956856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.