ArticleBMJ open2014
Physical activity and risk of fatty liver in people with different levels of alcohol consumption: a prospective cohort study.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Ethnicity matters: A Systematic Review and Meta-Analysis of the Non-Linear Relationship Between Alcohol Consumption and Prevalence and Incidence of Hepatic Steatosis.EBioMedicine · 2016Pooled it
- Accelerometer-derived moderate-to-vigorous physical activity and incident nonalcoholic fatty liver disease.BMC medicine · 2024Article
- Design and rationale for a randomized clinical trial testing the efficacy of a lifestyle physical activity intervention for people with HIV and engaged in unhealthy drinking.Contemporary clinical trials · 2024Article
- Associations of activity, sedentary and sleep behaviors with prevalent steatotic liver disease in middle-aged and older adults: the ELSA-Brasil study.Journal of activity, sedentary and sleep behaviors · 2024Article
- Diet quality and physical activity affect metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction and etiology-associated steatohepatitis, and compensated advanced chronic liver disease among United States adults: NHANES 2017-2020.Frontiers in nutrition · 2024Article
- A Smartphone Physical Activity App for Patients in Alcohol Treatment: Single-Arm Feasibility Trial.JMIR formative research · 2022Article
- Compositional data analysis of 24-hour movement behaviors and mental health in workers.Preventive medicine reports · 2020Article
- Exploration of Alcohol Consumption Behaviours and Health-Related Influencing Factors of Young Adults in the UK.International journal of environmental research and public health · 2020Article
- Incidence and causes of mildly to moderately elevated aminotransferase in Japanese patients with type 2 diabetes.Diabetology international · 2020Article
- Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults.Journal of exercise nutrition & biochemistry · 2018Article
- Association between physical activity and risk of nonalcoholic fatty liver disease: a meta-analysis.Therapeutic advances in gastroenterology · 2017Article
- Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009-2010).PloS one · 2017Article
- Article
Corrections and comments
- Erratum issuedCorrection.2015
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether physical activity affects the future incidence of fatty liver in people with never-moderate and heavy alcohol consumption.
designProspective cohort study.
settingHealth check-up programme at Meiji Yasuda Shinjuku Medical Center in Shinjuku Ward, Tokyo, Japan. POPULATION: A total of 10,146 people aged 18 years or older without fatty liver enrolled through baseline surveys conducted from 2005 to 2007. They were grouped into never-moderate alcohol drinkers (n=7803) and heavy alcohol drinkers (n=2343) and followed until 2013.
main outcome measureIncident fatty liver diagnosed by ultrasound.
resultsDuring a mean follow-up of 4.4 years (34,648 person-years), 1255 never-moderate alcohol drinkers developed fatty liver; 520 heavy alcohol drinkers developed fatty liver during a mean follow-up of 4.1 years (9596 person-years). For never-moderate alcohol drinkers, engaging in >3×/week of low-intensity (HR=0.82, 95% CI 0.71 to 0.96) and moderate-intensity (HR=0.56, 95% CI 0.39 to 0.81) physical activity significantly reduced incident fatty liver compared with those who engaged in physical activity <1×/week. For vigorous-intensity physical activity, frequencies of 2×/week (HR=0.57, 95% CI 0.38 to 0.86) and >3×/week (HR=0.55, 95% CI 0.38 to 0.79) were significantly associated with lower risk of incident fatty liver. In propensity-adjusted models, these significant associations still remained. By contrast, in heavy alcohol drinkers, there were no significant associations between the type or frequency of physical activity and incident fatty liver.
conclusionsPhysical activity had an independent protective effect on incident fatty liver only in the never-moderate alcohol drinkers, and the preventive effect increased with higher frequencies and intensities of physical activity.
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