ArticleBMC psychiatry2014
Alterations of regional homogeneity in pediatric bipolar depression: a resting-state fMRI study.
Article in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- The relationship between regional homogeneity in resting-state functional magnetic resonance imaging and cognitive function in depressive disorders with migraine.Scientific reports · 2025Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Resting-state functional connectivity indicators of risk and resilience for self-harm in adolescent bipolar disorder.Psychological medicine · 2023Article
- The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder.International journal of bipolar disorders · 2023Article
- Regional Homogeneity of the Left Posterior Cingulate Gyrus May Be a Potential Imaging Biomarker of Manic Episodes in First-Episode, Drug-Naive Bipolar Disorder.Neuropsychiatric disease and treatment · 2023Article
- The complexity of spontaneous brain activity changes in schizophrenia, bipolar disorder, and ADHD was examined using different variations of entropy.Human brain mapping · 2023Article
- Does the Brain Matter? Cortical Alterations in Pediatric Bipolar Disorder: A Critical Review of Structural and Functional Magnetic Resonance Studies.Current neuropharmacology · 2023Review
- Altered spatiotemporal consistency in pediatric bipolar disorder patients with and without psychotic symptoms.BMC psychiatry · 2021Article
- Cannabis use and resting state functional connectivity in adolescent bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2021Article
- Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques.BMC psychiatry · 2020Article
- Applying dimensional psychopathology: transdiagnostic associations among regional homogeneity, leptin and depressive symptoms.Translational psychiatry · 2020Article
- Altered Cortical Functional Networks in Patients With Schizophrenia and Bipolar Disorder: A Resting-State Electroencephalographic Study.Frontiers in psychiatry · 2020Article
- Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder.Neural plasticity · 2020Article
- Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder.Frontiers in psychiatry · 2020Article
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
- Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms.Neuroscience bulletin · 2019Article
- Relapsing-Remitting Multiple Sclerosis Is Associated With Regional Brain Activity Deficits in Motor- and Cognitive-Related Brain Areas.Frontiers in neurology · 2019Article
- Aberrant Functional Connectivity Patterns of Default Mode Network May Play a Key Role in the Interaction between Auditory Verbal Hallucinations and Insight.Chinese medical journal · 2018Article
- Decreased Functional Connectivity in Insular Subregions in Depressive Episodes of Bipolar Disorder and Major Depressive Disorder.Frontiers in neuroscience · 2018Article
- Regional Homogeneity and Multivariate Pattern Analysis of Cervical Spondylosis Neck Pain and the Modulation Effect of Treatment.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric bipolar disorder (PBD) has attracted increasing attentions due to its high prevalence and great influence on social functions of children and adolescents. However, the pathophysiology underlying PBD remains unclear. In the present study, the resting-state functional magnetic resonance imaging (fMRI) was used to detect abnormalities of baseline brain functions in depressed PBD youth.
methodsSeventeen youth with PBD-depression aged 10 - 18 years old and 18 age- and sex-matched normal controls were recruited in this study. The fMRI data under resting state were obtained on a Siemens 3.0 Tesla scanner and were analyzed using the regional homogeneity (ReHo) method. Correlations between the ReHo values of each survived area and the severity of depression symptoms in patients were further analyzed.
resultsAs compared with the control group, PBD-depression patients showed decreased ReHo in the medial frontal gyrus, bilateral middle frontal gyrus and middle temporal gyrus, and the right putamen. Significant negative correlations of the mood and feelings questionnaire scores with mean ReHo values in the medial frontal gyrus and the right middle frontal gyrus in PBD-depression patients were observed.
conclusionOur results suggest that extensive regions with altered baseline brain activities are existed in PBD-depression and these brain regions mainly locate in the fronto-limbic circuit and associated striatal structures. Moreover, the present findings also add to our understanding that there could be unique neuropathophysiological mechanisms underlying PBD-depression.
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