ArticleThe Journal of cell biology1989
Characterization of components of Z-bands in the fibrillar flight muscle of Drosophila melanogaster.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 112 citations in OpenAlex.
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- Localization of the Elastic Proteins in the Flight Muscle ofInternational journal of molecular sciences · 2020Article
- Kinetochore protein Spindly controls microtubule polarity inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Nanoscopy reveals the layered organization of the sarcomeric H-zone and I-band complexes.The Journal of cell biology · 2020Article
- Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.PLoS genetics · 2019Article
- A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs.Nature communications · 2015Article
- The Drosophila Z-disc protein Z(210) is an adult muscle isoform of Zasp52, which is required for normal myofibril organization in indirect flight muscles.The Journal of biological chemistry · 2013Article
- Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly.PLoS genetics · 2013Article
- Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.American journal of physiology. Cell physiology · 2011Article
- Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.The Journal of cell biology · 2011Article
- Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.Genes & development · 2011Article
- In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura.PloS one · 2010Article
- Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics.Biophysical journal · 2009Article
- Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The myofibrillar protein, projectin, is highly conserved across insect evolution except for its PEVK domain.Journal of molecular evolution · 2008Article
- The occurrence of tissue-specific twitchin isoforms in the mussel Mytilus galloprovincialis.Fisheries science : FS · 2008Article
- Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.Aging cell · 2008Article
- Mononuclear muscle cells in Drosophila ovaries revealed by GFP protein traps.Developmental biology · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Twelve monoclonal antibodies have been raised against proteins in preparations of Z-disks isolated from Drosophila melanogaster flight muscle. The monoclonal antibodies that recognized Z-band components were identified by immunofluorescence microscopy of flight muscle myofibrils. These antibodies have identified three Z-disk antigens on immunoblots of myofibrillar proteins. Monoclonal antibodies alpha:1-4 recognize a 90-100-kD protein which we identify as alpha-actinin on the basis of cross-reactivity with antibodies raised against honeybee and vertebrate alpha-actinins. Monoclonal antibodies P:1-4 bind to the high molecular mass protein, projectin, a component of connecting filaments that link the ends of thick filaments to the Z-band in insect asynchronous flight muscles. The anti-projectin antibodies also stain synchronous muscle, but, surprisingly, the epitopes here are within the A-bands, not between the A- and Z-bands, as in flight muscle. Monoclonal antibodies Z(210):1-4 recognize a 210-kD protein that has not been previously shown to be a Z-band structural component. A fourth antigen, resolved as a doublet (approximately 400/600 kD) on immunoblots of Drosophila fibrillar proteins, is detected by a cross reacting antibody, Z(400):2, raised against a protein in isolated honeybee Z-disks. On Lowicryl sections of asynchronous flight muscle, indirect immunogold staining has localized alpha-actinin and the 210-kD protein throughout the matrix of the Z-band, projectin between the Z- and A-bands, and the 400/600-kD components at the I-band/Z-band junction. Drosophila alpha-actinin, projectin, and the 400/600-kD components share some antigenic determinants with corresponding honeybee proteins, but no honeybee protein interacts with any of the Z(210) antibodies.
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