Evidence map›Paper›PMID 25094042›Full record

ArticleVirology2014

MHC basis of T cell-dependent heterologous immunity to arenaviruses.

Keith A Daniels, Steven D Hatfield, Raymond M Welsh, Michael A Brehm

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Keith A DanielsDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Steven D HatfieldDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Raymond M WelshDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: raymond.welsh@umassmed.edu.
Michael A BrehmProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
University of Massachusetts Chan Medical School · US

Funding

Virology and Technology CoreP01AI046629 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GREINER, DALE LESLIE · 1999 to 2014
$19.1M
T cell and transgenic core U19AI109858 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 2014 to 2018
$11.9M
Virus induced immunopathologyR01AI081675 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 2009 to 2013
$2.0M
NIAID NIH HHS AI046629NIAID NIH HHS AI081675NIAID NIH HHS P01 AI046629NIAID NIH HHS R01 AI081675NIAID NIH HHS U19 AI109858
6 · The paper itself

Abstract

Having a history of infection with one pathogen may sometimes provide a level of T cell-dependent protective heterologous immunity to another pathogen. This immunity was initially thought due to cross-reactive T cell epitopes, but recent work has suggested that such protective immunity can be initiated nonspecifically by the action of cytokines on memory T cells. We retested this concept using two small and well-defined arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PV), and found that heterologous immunity in these systems was indeed linked to T cell epitopes and the major histocompatibility complex.

Indexed as

Immunity, HeterologousMajor Histocompatibility ComplexAnimalsArenaviridae InfectionsCD8-Positive T-LymphocytesCross ProtectionCross ReactionsEpitopes, T-LymphocyteHumansLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLPichinde virusEpitopes, T-LymphocyteArenavirusesCross-reactivity CD8 T cellEpitopesHeterologous immunityLymphocytic choriomeningitis virusPichinde virus

Identifiers

PMID25094042
PMCPMC4196705
OpenAlexW2046325273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.