Evidence map›Paper›PMID 25093974›Full record

ArticleThe Pediatric infectious disease journal2015

Evaluation of QuantiFERON-TB gold in-tube and tuberculin skin tests among immigrant children being screened for latent tuberculosis infection.

Meredith M Howley, John A Painter, Dolores J Katz, Edward A Graviss, Randall Reves, Suzanne F Beavers, Denise O Garrett, Tuberculosis Epidemiologic Studies Consortium

Open access · greenAbstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Latent tuberculosis in migrants travelling through the northeast regions of Mexico.Journal of clinical tuberculosis and other mycobacterial diseases · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Too little too late: Waiting for TB to come.The Indian journal of tuberculosis · 2018
    Review
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Meredith M HowleyFrom the *Centers for Disease Control and Prevention, Atlanta, GA; †Methodist Hospital Research Institute, Houston, TX; and ‡Denver Health and Hospital Authority, Denver, CO.
John A Painter
Dolores J Katz
Edward A Graviss
Randall Reves
Suzanne F Beavers
Denise O Garrett
Tuberculosis Epidemiologic Studies Consortium
Centers for Disease Control and Prevention · USMethodist Hospital · USUniversity of Colorado Denver · US

Funding

Intramural CDC HHS CC999999NCBDD CDC HHS U01 DD001304
6 · The paper itself

Abstract

backgroundCenters for Disease Control and Prevention requirements for pre-immigration tuberculosis (TB) screening of children 2- to 14-years old permit a tuberculin skin test (TST) or an interferon-gamma release assay (IGRA). Few data are available on the performance of IGRAs versus TSTs in foreign-born children.

methodsWe compared the performance of TST and QuantiFERON-TB (QFT) Gold In-Tube in children 2- to 14-years old applying to immigrate to the United States from Mexico, the Philippines and Vietnam, using diagnosis of TB in immigrating family members as a measure of potential exposure.

resultsWe enrolled 2520 children: 664 (26%) were TST+ and 142 (5.6%) were QFT+. One hundred and eleven (4.4%) were TST+/QFT+, 553 (21.9%) were TST+/QFT- and 31 (1.2%) were TST-/QFT+. Agreement between tests was poor (κ = 0.20). Although positive results of both tests were significantly associated with older age (relative risks [RR] TST+, 1.64; 95% confidence interval [CI]: 1.36-1.97; RR QFT+, 3.05; 95% CI: 1.72-5.38) and with the presence of TB in at least 1 immigrating family member (RR TST+, 1.40; 95% CI: 1.12-1.75; RR QFT+ 2.24; 95% CI: 1.18-4.28), QFT+ results were more strongly associated with both predictive variables.

conclusionsThe findings support the preferential use of QFT over TST for pre-immigration screening of foreign-born children 2 years of age and older and lend support to the preferential use of IGRAs in testing foreign-born children for latent TB infection.

Indexed as

Emigrants and ImmigrantsAdolescentChildChild, PreschoolFemaleHumansInterferon-gamma Release TestsLatent TuberculosisMaleMass ScreeningProspective StudiesSkin TestsTuberculin TestUnited States

Identifiers

PMID25093974
PMCPMC5136477
OpenAlexW2327015301

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.