Evidence map›Paper›PMID 25093862›Full record

ArticlePloS one2014

Green tea extract treatment alleviates ocular inflammation in a rat model of endotoxin-induced uveitis.

Yong Jie Qin, Kai On Chu, Yolanda Wong Ying Yip, Wai Ying Li, Ya Ping Yang, Kwok Ping Chan, Jia Lin Ren, Sun On Chan, Chi Pui Pang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

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  14. Effects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yong Jie QinDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Kai On ChuDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Yolanda Wong Ying YipDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Wai Ying LiDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Ya Ping YangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Kwok Ping ChanDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Jia Lin RenSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Sun On ChanSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Chi Pui PangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Chinese University of Hong Kong · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Green tea extract (GTE) ingested by rats exerted anti-oxidative activities in various ocular tissues as shown in our previous studies. The present work investigated anti-inflammatory effects of GTE on endotoxin-induced uveitis (EIU). EIU was generated in adult rats by a footpad injection of 1 mg/kg lipopolysaccharide (LPS). Oral administration of GTE (550 mg/kg) was given one, two or four times after LPS injection. Twenty-four hours later, LPS produced severe hyperemia and edema in the iris. Immunocytochemical examinations showed an accumulation of infiltrating cells in the aqueous humor that were immunopositive for cluster of differentiation 43 (CD43) and CD68, markers for leucocytes and macrophages, respectively. Analyses of the aqueous humor showed an increase in pro-inflammatory mediators including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1). GTE treatments improved the clinical manifestations and reduced infiltrating cells and protein exudation in the aqueous humor, which were not observed under half dose of GTE (275 mg/kg). The number of CD68 positive macrophages residing in the iris and ciliary was also reduced. GTE suppressed production of TNF-α, IL-6 and MCP-1 in the aqueous humor, which was associated with a down-regulation of LPS receptor complex subunits, Toll-like receptor 4 (TLR-4) and CD14, and suppression of nuclear factor-kappa Bp65 (NF-κBp65) in the iris and ciliary body. Our findings show that GTE is a potent anti-inflammatory agent against the inflammation of EIU, and suggest a potential use in treatment of acute uveitis.

Indexed as

TeaAnimalsAqueous HumorCatechinDisease Models, AnimalEndotoxinsInflammationLipopolysaccharidesNeutrophil InfiltrationPlant ExtractsRatsRats, Sprague-DawleyUveitisCatechinEndotoxinsepigallocatechin gallateLipopolysaccharidesPlant ExtractsTea

Identifiers

PMID25093862
PMCPMC4122397
OpenAlexW2095373091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.