Evidence map›Paper›PMID 25093746›Full record

ArticleChimerism2014

Maternal microchimerism: friend or foe in type 1 diabetes?

Jody Ye, Marta Vives-Pi, Kathleen M Gillespie

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Chimerism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. How pregnancy can affect autoimmune diseases progression?Clinical and molecular allergy : CMA · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jody YeDiabetes and Metabolism Unit; School of Clinical Sciences; University of Bristol; Bristol, UK.
Marta Vives-PiDepartment of Immunology; Germans Trias i Pujol Research Institute; Autonomous University of Barcelona; Badalona, Spain.
Kathleen M GillespieDiabetes and Metabolism Unit; School of Clinical Sciences; University of Bristol; Bristol, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic, supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.

Indexed as

Diabetes Mellitus, Type 1FemaleHumansInsulinMaleMaternal-Fetal ExchangePancreasPregnancyInsulinmaternal microchimerismtype 1 diabetes

Identifiers

PMID25093746
PMCPMC4199804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.