ArticleMenopause (New York, N.Y.)2015
Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women.
Article in Menopause (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- The impact of vitamin D supplementation on anti-Müllerian hormone levels: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- The auxiliary effect of oral nutritional supplements on fertility in women with diminished ovarian reserve: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- A systematic review and meta-analysis of the association between vitamin D and ovarian reserve.Scientific reports · 2021Pooled it
- The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Vitamin D metabolites across the menstrual cycle: a systematic review.BMC women's health · 2019Pooled it
- Current Evidence on Associations of Nutritional Factors with Ovarian Reserve and Timing of Menopause: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- Vitamin D Status and Reproductive Hormonal Profiles in Early Versus Physiological Menopause: A Comparative Observational Study.Biomedicines · 2026Article
- Association between the nutritional risk index and postmenopausal osteoporosis in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2026Article
- Supplement strategies for infertility in overweight women: Evidence and legal insights.Open medicine (Warsaw, Poland) · 2025Review
- Vitamin D status and supplementation, calcium supplementation, and timing of natural menopause.Maturitas · 2024Article
- The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review.Nutrients · 2023Review
- Observational
- A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females.Food science & nutrition · 2023Review
- Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review.Reproductive biology and endocrinology : RB&E · 2022Review
- Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women.Scientific reports · 2022Article
- Ultraviolet radiation and age at natural menopause in a nationwide, prospective US cohort.Environmental research · 2022Article
- Can Nutrition Help in the Treatment of Infertility?Preventive nutrition and food science · 2021Review
- Vitamin D in follicular development and oocyte maturation.Reproduction (Cambridge, England) · 2021Review
- Age at Natural Menopause; A Data Mining Approach (Data from the National Health and Nutrition Examination Survey 2013-2014).International journal of preventive medicine · 2021Article
- Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link?Obstetrics & gynecology science · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveVitamin D has been linked to antimüllerian hormone levels, suggesting a possible association with greater ovarian reserve, but large population-based studies are lacking. Our objective was to explore the association between vitamin D and follicle-stimulating hormone (FSH) in premenopausal women.
methodsThe Uterine Fibroid Study (1996-1999) enrolled randomly selected 30- to 49-year-old members of a Washington, DC, health plan (N = 1,430). Women provided blood and urine samples in addition to questionnaire data. The vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) was measured in stored plasma samples. Urinary FSH (mIU/mg creatinine) was measured by immunofluorometric assay. To obtain baseline measures, we limited this investigation to urine samples collected in the first 5 days of the menstrual cycle or 5 days before menses onset. In addition, postmenopausal women and women using oral contraceptives were excluded, leaving 527 women for analysis. FSH was creatinine-adjusted, normalized by log transformation, and modeled with multivariable linear regression.
resultsThe median 25(OH)D level was 12 ng/mL, with approximately 75% of participants below the recommended level of 20 ng/mL. FSH and 25(OH)D were inversely related. For every 10-ng/mL increase in 25(OH)D, urinary FSH decreased by 14% (95% CI, -23 to -5; P = 0.003).
conclusionsVitamin D is inversely related to FSH. This is consistent with literature relating low vitamin D levels to lower antimüllerian hormone levels. Prospective studies should investigate whether low vitamin D levels contribute to decreased ovarian reserve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.