Evidence map›Paper›PMID 25093702›Full record

SynthesisNeuroscience letters2014

Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder.

Susanne Walitza, Zoya Marinova, Edna Grünblatt, Stanley E Lazic, Helmut Remschmidt, Timo D Vloet, Jens R Wendland

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021
    Pooled it
  2. Trial
  3. Brain-Behavior Relationships: Neural Mechanisms of Impulsivity and Compulsivity in Neuropsychiatric Disorders.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2025
    Review
  4. Optogenetic Stimulation of Novel Tph2-Cre Rats Advances Insight into Serotonin's Role in Locomotion, Reinforcement, and Compulsivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Review
  6. Article
  7. Genetics of obsessive-compulsive disorder.Indian journal of psychiatry · 2019
    Review
  8. Article
  9. Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Susanne WalitzaUniversity Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland; Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Germany; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Switzerland. Electronic address: Susanne.Walitza@kjpdzh.ch.
Zoya MarinovaUniversity Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland. Electronic address: zoya.marinova@kjpdzh.ch.
Edna GrünblattUniversity Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Switzerland; Department of Psychiatry, Psychosomatic and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
Stanley E LazicIn Silico Lead Discovery, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Helmut RemschmidtDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, Germany.
Timo D VloetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Technical University of Aachen, Germany.
Jens R WendlandLaboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA.
University of Zurich · CHETH Zurich · CHFH Aachen · DENational Institute of Mental Health · USNovartis Institutes for BioMedical ResearchPhilipps University of Marburg · DE

Funding

The Genetics of Obsessive Compulsive Disorder and Related OCD Spectrum DisordersZIAMH000336 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MURPHY, DENNIS L · 2009 to 2014
$4.8M
THE PSYCHOLBIOLOGY AND TREATMENT OF OBESSIVE-COMPULSIVE DISORDER IN ADULTSZ01MH000336 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MURPHY, DENNIS L · 1985 to 2008
$937k
Intramural NIH HHS Z01 MH000336Intramural NIH HHS ZIA MH000336NIMH NIH HHS MH000336-30
6 · The paper itself

Abstract

Despite compelling evidence for major genetic contributions to the etiology of obsessive-compulsive disorder (OCD), few genetic variants have been consistently associated with this debilitating illness. Molecular genetic studies in children and adolescents with OCD are of particular interest, since early onset of the disease has been observed to be associated with increased familiality. We replicate here for the first time in early-onset OCD patients, a previously reported association of OCD with the common gain-of-function LA allele at the serotonin transporter linked polymorphic region known as 5-HTTLPR in a collection of parent-offspring trios. The present meta-analysis of this recently refined serotonin transporter gene variant revealed further support for the LA allele conferring increased genetic susceptibility to OCD. We conclude that the 5-HTTLPR is currently the single best supported risk variant for OCD, in regards of early-onset OCD, albeit of modest effect size and the possibility that the conferred risk might not be specific to OCD.

Indexed as

Genetic VariationAdultAge of OnsetChildGenetic Association StudiesGenetic Predisposition to DiseaseHumansObsessive-Compulsive DisorderSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport Proteins5-HTTLPRMeta-analysisObsessive–compulsive disorderSerotonin transporterTransmission disequilibrium test

Identifiers

PMID25093702
PMCPMC4167890
OpenAlexW2042114770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.