ArticleThe ISME journal2014
Comparative single-cell genomics reveals potential ecological niches for the freshwater acI Actinobacteria lineage.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 180 citations in OpenAlex.
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- Seasonal variation in bacterial community composition in the brackish meromictic Lake Suigetsu.Antonie van Leeuwenhoek · 2025Article
- Widely-distributed freshwater microorganisms with streamlined genomes co-occur in cohorts with high abundance.Scientific reports · 2025Article
- Tetranucleotide frequencies differentiate genomic boundaries and metabolic strategies across environmental microbiomes.mSystems · 2025Article
- Microbial communities in glacial lakes of Glacier National Park, MT, USA.FEMS microbiology ecology · 2025Article
- Occurrence of antibiotics and antibiotic resistance genes at various stages of different aquaculture modes surrounding Tai Lake, China.Frontiers in microbiology · 2025Article
- Genome editing in ubiquitous freshwater Actinobacteria.Applied and environmental microbiology · 2024Article
- Extreme trophic tales: deciphering bacterial diversity and potential functions in oligotrophic and hypereutrophic lakes.BMC microbiology · 2024Article
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- Bacterial and fungal community structures in Hulun Lake are regulated by both stochastic processes and environmental factors.Microbiology spectrum · 2024Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 7 institutions in 4 countries.
Funding
Abstract
Members of the acI lineage of Actinobacteria are the most abundant microorganisms in most freshwater lakes; however, our understanding of the keys to their success and their role in carbon and nutrient cycling in freshwater systems has been hampered by the lack of pure cultures and genomes. We obtained draft genome assemblies from 11 single cells representing three acI tribes (acI-A1, acI-A7, acI-B1) from four temperate lakes in the United States and Europe. Comparative analysis of acI SAGs and other available freshwater bacterial genomes showed that acI has more gene content directed toward carbohydrate acquisition as compared to Polynucleobacter and LD12 Alphaproteobacteria, which seem to specialize more on carboxylic acids. The acI genomes contain actinorhodopsin as well as some genes involved in anaplerotic carbon fixation indicating the capacity to supplement their known heterotrophic lifestyle. Genome-level differences between the acI-A and acI-B clades suggest specialization at the clade level for carbon substrate acquisition. Overall, the acI genomes appear to be highly streamlined versions of Actinobacteria that include some genes allowing it to take advantage of sunlight and N-rich organic compounds such as polyamines, di- and oligopeptides, branched-chain amino acids and cyanophycin. This work significantly expands the known metabolic potential of the cosmopolitan freshwater acI lineage and its ecological and genetic traits.
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