ArticleMagnetic resonance imaging2014
Longitudinal assessment of mouse renal injury using high-resolution anatomic and magnetization transfer MR imaging.
Article in Magnetic resonance imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Multimodal Magnetic Resonance Imaging in Diabetic Kidney Disease: From Pathophysiological Insights to Clinical Applications.Diagnostics (Basel, Switzerland) · 2026Review
- Functional Microendoscopy Reveals Calcium Responses of Single Cells in Tracheal Tuft Cells and Kidney Podocytes.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Severity of polycystic kidney disease revealed by multiparametric MRI.Magnetic resonance in medicine · 2023Article
- Multiparametric magnetic resonance imaging in diagnosis of long-term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice.NMR in biomedicine · 2022Article
- Renal tubular dilation and fibrosis after unilateral ureter obstruction revealed by relaxometry and spin-lock exchange MRI.NMR in biomedicine · 2021Article
- The Vanderbilt O'Brien Kidney Center.American journal of physiology. Renal physiology · 2021Review
- Spin-lock relaxation rate dispersion reveals spatiotemporal changes associated with tubulointerstitial fibrosis in murine kidney.Magnetic resonance in medicine · 2020Article
- Noninvasive quantitative magnetization transfer MRI reveals tubulointerstitial fibrosis in murine kidney.NMR in biomedicine · 2019Article
- Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Multiparametric Functional Magnetic Resonance Imaging for Evaluating Renal Allograft Injury.Korean journal of radiology · 2019Review
- Spatiotemporal trajectories of quantitative magnetization transfer measurements in injured spinal cord using simplified acquisitions.NeuroImage. Clinical · 2019Article
- Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI.Magnetic resonance in medicine · 2018Article
- Assessment of unilateral ureter obstruction with multi-parametric MRI.Magnetic resonance in medicine · 2018Article
- Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.PloS one · 2018Article
- Magnetization Transfer Magnetic Resonance Imaging Noninvasively Detects Renal Fibrosis in Swine Atherosclerotic Renal Artery Stenosis at 3.0 T.Investigative radiology · 2017Article
- Noninvasive Assessment of Renal Fibrosis with Magnetization Transfer MR Imaging: Validation and Evaluation in Murine Renal Artery Stenosis.Radiology · 2017Article
- MRI tools for assessment of microstructure and nephron function of the kidney.American journal of physiology. Renal physiology · 2016Review
- Mapping murine diabetic kidney disease using chemical exchange saturation transfer MRI.Magnetic resonance in medicine · 2016Article
- Radiologic imaging of the renal parenchyma structure and function.Nature reviews. Nephrology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The purpose of this study is to evaluate the utility of high-resolution non-invasive endogenous high-field MRI methods for the longitudinal structural and quantitative assessments of mouse kidney disease using the model of unilateral ureter obstruction (UUO). T1-weighted, T2-weighted and magnetization transfer (MT) imaging protocols were optimized to improve the regional contrast in mouse kidney. Conventional T1 and T2 weighted images were collected in UUO mice on day 0 (~3h), day 1, day 3 and day 6 after injury, on a 7 T small animal MRI system. Cortical and medullary thickness, corticomedullary contrast and Magnetization Transfer Ratio (MTR) were assessed longitudinally. Masson trichrome staining was used to histologically assess changes in tissue microstructure. Over the course of UUO progression there were significant (p<0.05) changes in thickness of cortex and outer medulla, and regional changes in T2 signal intensity and MTR values. Histological changes included tubular cell death, tubular dilation, urine retention, and interstitial fibrosis, assessed by histology. The MRI measures of renal cortical and medullary atrophy, cortical-medullary differentiation and MTR changes provide an endogenous, non-invasive and quantitative evaluation of renal morphology and tissue composition during UUO progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.