ArticleThe Journal of clinical endocrinology and metabolism2014
Cardiac structure and function in Cushing's syndrome: a cardiac magnetic resonance imaging study.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03880513 (Cardiovascular Status in Patients With Endogenous Cortisol Excess), which is not on this map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Status in Patients With Endogenous Cortisol Excess (Cushing's Syndrome)
Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
- Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis.The Journal of clinical endocrinology and metabolism · 2026Article
- European survey on metabolic and cardiovascular risk in Cushing syndrome.Journal of endocrinological investigation · 2025Article
- Determinants of QTc Interval Prolongation in Patients with Hypopituitarism and Other Pituitary Disorders.Biomedicines · 2025Article
- Cardiomyopathies of endocrine origin: A state-of-the-art review.World journal of cardiology · 2025Review
- Cardiac function in children with congenital adrenal hyperplasia.Journal of pediatric endocrinology & metabolism : JPEM · 2025Article
- Osilodrostat Safety Profile: Findings from Real-World Data in the FAERS Database.Journal of clinical medicine · 2025Article
- The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis.Cardiovascular diabetology · 2025Article
- Association Between Longitudinal Changes in Left Ventricular Structure and Function and 24-Hour Urinary Free Cortisol in Essential Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing's syndrome.Endocrine connections · 2025Article
- Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease.Scientific reports · 2025Observational
- Serum Cortisol and Cardiovascular Disease Risk - A Potential Biomarker.Current cardiology reviews · 2025Review
- Cardiac magnetic resonance reveals biventricular impairment in Cushing's syndrome: a multicentre case-control study.Endocrine · 2024Article
- Cardiac disease in Cushing's syndrome. Emphasis on the role of cardiovascular magnetic resonance imaging.Endocrine · 2024Review
- Clinical features and risk factors for postoperative recurrence in patients with Cushing's syndrome of different etiologies.Scientific reports · 2024Article
- Clinical and cardiac characteristics of primary bilateral macronodular adrenal hyperplasia.Journal of medical biochemistry · 2024Article
- Role of cardiovascular magnetic resonance in the clinical evaluation of left ventricular hypertrophy: a 360° panorama.The international journal of cardiovascular imaging · 2023Review
- Ectopic lipid metabolism in anterior pituitary dysfunction.Frontiers in endocrinology · 2023Review
- Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients-Literature Review.Journal of clinical medicine · 2022Review
- Cardiovascular health and mortality in Cushing's disease.Pituitary · 2022Review
- Cardiovascular complications of Cushings syndrome: Impact on morbidity and mortality.Journal of neuroendocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with Cushing's syndrome have left ventricular (LV) hypertrophy and dysfunction on echocardiography, but echo-based measurements may have limited accuracy in obese patients. No data are available on right ventricular (RV) and left atrial (LA) size and function in these patients.
objectivesThe objective of the study was to evaluate LV, RV, and LA structure and function in patients with Cushing's syndrome by means of cardiac magnetic resonance, currently the reference modality in assessment of cardiac geometry and function.
methodsEighteen patients with active Cushing's syndrome and 18 volunteers matched for age, sex, and body mass index were studied by cardiac magnetic resonance. The imaging was repeated in the patients 6 months (range 2-12 mo) after the treatment of hypercortisolism.
resultsCompared with controls, patients with Cushing's syndrome had lower LV, RV, and LA ejection fractions (P < .001 for all) and increased end-diastolic LV segmental thickness (P < .001). Treatment of hypercortisolism was associated with an improvement in ventricular and atrial systolic performance, as reflected by a 15% increase in the LV ejection fraction (P = .029), a 45% increase in the LA ejection fraction (P < .001), and an 11% increase in the RV ejection fraction (P = NS). After treatment, the LV mass index and end-diastolic LV mass to volume ratio decreased by 17% (P < .001) and 10% (P = .002), respectively. None of the patients had late gadolinium myocardial enhancement.
conclusionCushing's syndrome is associated with subclinical biventricular and LA systolic dysfunctions that are reversible after treatment. Despite skeletal muscle atrophy, Cushing's syndrome patients have an increased LV mass, reversible upon correction of hypercortisolism.
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