ArticleJournal of natural products2014
Greensporones: resorcylic acid lactones from an aquatic Halenospora sp.
Article in Journal of natural products, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Natural Products of Freshwater Fungi from a Chemical and Bioactive Perspective.Journal of fungi (Basel, Switzerland) · 2026Review
- Extracting Value from Marine and Microbial Natural Product Artifacts and Chemical Reactivity.Marine drugs · 2025Review
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Homoisoflavonoids from the bulbs of Bellevalia longipes and an assessment of their potential cytotoxic activity.Phytochemistry · 2022Article
- Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol.Journal of natural products · 2022Review
- Fungal-fungal co-culture: a primer for generating chemical diversity.Natural product reports · 2022Review
- Metabolomics-Guided Comparison of Pollen and Microalgae-Based Artificial Diets in Honey Bees.Journal of agricultural and food chemistry · 2022Article
- Polychlorinated cyclopentenes from a marine derived Periconia sp. (strain G1144).Phytochemistry · 2022Article
- Discovery of Anticancer Agents of Diverse Natural Origin.Journal of natural products · 2022Article
- Dereplication of Fungal Metabolites by NMR-Based Compound Networking Using MADByTE.Journal of natural products · 2022Article
- Medicinal potentialities and pathogenic profile of Lasiodiplodia genus.World journal of microbiology & biotechnology · 2021Review
- Article
- Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis.The Journal of antibiotics · 2021Article
- Coumarins, dihydroisocoumarins, a dibenzo-Tetrahedron letters · 2021Article
- Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations.Journal of natural products · 2021Article
- Freshwater Fungi as a Source of Chemical Diversity: A Review.Journal of natural products · 2021Review
- Article
- Orthogonal Method for Double-Bond Placement via Ozone-Induced Dissociation Mass Spectrometry (OzID-MS).Journal of natural products · 2019Article
- Engineering Fluorine into Verticillins (Epipolythiodioxopiperazine Alkaloids) via Precursor-Directed Biosynthesis.Journal of natural products · 2019Article
- Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic FungusMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Fourteen new resorcylic acid lactones (1-14) were isolated from an organic extract of a culture of a freshwater aquatic fungus Halenospora sp. originating from a stream in North Carolina. The structures were elucidated using a set of spectroscopic and spectrometric techniques. The absolute configuration of one representative member of the compounds (7) was assigned using X-ray crystallography of an analogue that incorporated a heavy atom, whereas for compounds 8-11, a modified Mosher's ester method was utilized. The relative configurations of compounds 12-14 were determined on the basis of NOE data. Compounds 12-14 were proposed as artifacts produced by intramolecular cycloetherification of the ε-hydroxy-α,β-unsaturated ketone moieties of the parent compounds during the purification processes. The isolated compounds, except for 8 and 12, were tested against the MDA-MB-435 (melanoma) and HT-29 (colon) cancer cell lines. Compound 5 was the most potent, with IC50 values of 2.9 and 7.5 μM, respectively. The compounds were evaluated as TAK1-TAB1 inhibitors but were found to be inactive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.