ArticleBioMed research international2014
Angiogenin expression during early human placental development; association with blood vessel formation.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
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- Cadmium reduces growth of male fetuses by impairing development of the placental vasculature and reducing expression of nutrient transporters.Toxicology and applied pharmacology · 2023Article
- Prenatal exercise in fetal development: a placental perspective.The FEBS journal · 2022Review
- Emerging biological functions of ribonuclease 1 and angiogenin.Critical reviews in biochemistry and molecular biology · 2022Review
- Reactive Oxygen Species are Essential for Placental Angiogenesis During Early Gestation.Oxidative medicine and cellular longevity · 2022Article
- CXCL1 stimulates decidual angiogenesis via the VEGF-A pathway during the first trimester of pregnancy.Molecular and cellular biochemistry · 2021Article
- Assessment of ANG variants in Parkinson's disease.Neurobiology of aging · 2021Article
- RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.Biology open · 2021Article
- Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVEC angiogenesis in vitro.Stem cell research & therapy · 2021Article
- Characterization of Naturally Occurring Bioactive Factor Mixtures for Bone Regeneration.International journal of molecular sciences · 2020Article
- Cellular Based Strategies for Microvascular Engineering.Stem cell reviews and reports · 2019Review
- Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling.Current hypertension reports · 2017Review
- Villi-specific Gene Expression Reveals Novel Prognostic Biomarkers in Multiple Human Cancers.Journal of Cancer · 2017Article
- Abundance of RNase4 and RNase5 mRNA and protein in host defence related tissues and secretions in cattle.Biochemistry and biophysics reports · 2016Article
- Three decades of research on angiogenin: a review and perspective.Acta biochimica et biophysica Sinica · 2016Review
- Skin telocytes versus fibroblasts: two distinct dermal cell populations.Journal of cellular and molecular medicine · 2015Article
- Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.Progress in retinal and eye research · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The placenta is a transient organ essential for fetal development. During human placental development, chorionic villi grow in coordination with a large capillary network resulting from both vasculogenesis and angiogenesis. Angiogenin is one of the most potent inducers of neovascularisation in experimental models in vivo. We and others have previously mapped angiogenin expression in the human term placenta. Here, we explored angiogenin involvement in early human placental development. We studied, angiogenin expression by in situ hybridisation and/or by RT-PCR in tissues and primary cultured trophoblastic cells and angiogenin cellular distribution by coimmunolabelling with cell markers: CD31 (PECAM-1), vascular endothelial cadherin (VE-cadherin), vascular endothelial growth factor receptor-2 (VEGF-R2), Tie-2, von Willebrand factor, CD34, erythropoeitin receptor (Epo-R), alpha-smooth muscle actin, CD45, cytokeratin 7, and Ki-67. Extravillous and villous cytotrophoblasts, isolated and differentiated in vitro, expressed and secreted angiogenin. Angiogenin was detected in villous trophoblastic layers, and structured and nascent fetal vessels. In decidua, it was expressed by glandular epithelial cells, vascular cells and macrophages. The observed pattern of angiogenin expression is compatible with a role in blood vessel formation and in cross-talk between trophoblasts and endothelial cells. In view of angiogenin properties, we suggest that angiogenin may participate in placental vasculogenesis and organogenesis.
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